Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation.

Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation.

Aldosterone promotes non-genomic effects in endothelial and vascular smooth muscle cells via activation of mineralocorticoid receptors (MR) and G protein-coupled estrogen receptors (GPER). GPER activation is associated with beneficial/protective effects in the vasculature. Considering that vascular...

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Bibliographic Details
Main Authors: Nathanne Santos Ferreira, Stêfany Bruno Assis Cau, Marcondes Alves Barbosa Silva, Carla Pavan Manzato, Fabíola Leslie Antunes Cardoso Mestriner, Takayuki eMatsumoto, Fernando Silva Carneiro, Rita Cassia Tostes
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Aldosterone
Mesenteric Arteries
diabetes
mineralocorticoid receptor
G protein-coupled estrogen receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00034/full

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