Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring
As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antia...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/8/1613 |
| _version_ | 1797538136584093696 |
|---|---|
| author | Alessandro Crosio Giulia Ronchi Benedetta Elena Fornasari Simonetta Odella Stefania Raimondo Pierluigi Tos |
| author_facet | Alessandro Crosio Giulia Ronchi Benedetta Elena Fornasari Simonetta Odella Stefania Raimondo Pierluigi Tos |
| author_sort | Alessandro Crosio |
| collection | DOAJ |
| description | As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices. |
| first_indexed | 2024-03-10T12:26:14Z |
| format | Article |
| id | doaj.art-9492f1a3e15e426d99d118d9e2b632c1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:26:14Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9492f1a3e15e426d99d118d9e2b632c12023-11-21T15:00:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01108161310.3390/jcm10081613Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve ScarringAlessandro Crosio0Giulia Ronchi1Benedetta Elena Fornasari2Simonetta Odella3Stefania Raimondo4Pierluigi Tos5UO Microchirurgia e Chirurgia della Mano, Ospedale Gaetano Pini, Piazza Andrea Ferrari 1, 20122 Milano, ItalyDepartment of Clinical and Biological Sciences, Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO), University of Turin, Regione Gonzole 10, 10043 Orbassano, ItalyDepartment of Clinical and Biological Sciences, Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO), University of Turin, Regione Gonzole 10, 10043 Orbassano, ItalyUO Microchirurgia e Chirurgia della Mano, Ospedale Gaetano Pini, Piazza Andrea Ferrari 1, 20122 Milano, ItalyDepartment of Clinical and Biological Sciences, Neuroscience Institute of the “Cavalieri Ottolenghi” Foundation (NICO), University of Turin, Regione Gonzole 10, 10043 Orbassano, ItalyUO Microchirurgia e Chirurgia della Mano, Ospedale Gaetano Pini, Piazza Andrea Ferrari 1, 20122 Milano, ItalyAs a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices.https://www.mdpi.com/2077-0383/10/8/1613scar tissueperipheral nerve regenerationantiadhesion devicesanimal models |
| spellingShingle | Alessandro Crosio Giulia Ronchi Benedetta Elena Fornasari Simonetta Odella Stefania Raimondo Pierluigi Tos Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring Journal of Clinical Medicine scar tissue peripheral nerve regeneration antiadhesion devices animal models |
| title | Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring |
| title_full | Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring |
| title_fullStr | Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring |
| title_full_unstemmed | Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring |
| title_short | Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring |
| title_sort | experimental methods to simulate and evaluate postsurgical peripheral nerve scarring |
| topic | scar tissue peripheral nerve regeneration antiadhesion devices animal models |
| url | https://www.mdpi.com/2077-0383/10/8/1613 |
| work_keys_str_mv | AT alessandrocrosio experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring AT giuliaronchi experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring AT benedettaelenafornasari experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring AT simonettaodella experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring AT stefaniaraimondo experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring AT pierluigitos experimentalmethodstosimulateandevaluatepostsurgicalperipheralnervescarring |