Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank
Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure, while the role of genetics and incident cardiovascular disease (CVD) remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major deme...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/1/e101209.full |
| _version_ | 1797272232990343168 |
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| author | Ting Li Jing Chen Yan Zheng Klodian Dhana Geng Zong Yuan Ma Trudy Voortman Wei Gan Yaying Cao Yonghua Hu Changzheng Yuan Jie Shen Gaohong Zhu Chengwu Feng |
| author_facet | Ting Li Jing Chen Yan Zheng Klodian Dhana Geng Zong Yuan Ma Trudy Voortman Wei Gan Yaying Cao Yonghua Hu Changzheng Yuan Jie Shen Gaohong Zhu Chengwu Feng |
| author_sort | Ting Li |
| collection | DOAJ |
| description | Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure, while the role of genetics and incident cardiovascular disease (CVD) remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample, and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia (2006–2010, mean age 56.4 years) was conducted within the UK Biobank, with brain magnetic resonance imaging (MRI) measurement available for 15 104 participants since 2014. CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score (FGCRS). Dementia diagnosis was ascertained from inpatient and death register data.Results Over a median 12.0-year follow-up, 3998 all-cause dementia cases were identified. Higher FGCRS was associated with increased all-cause dementia risk after adjusting for demographic, major lifestyle, clinical factors and the polygenic risk score (PRS) of Alzheimer’s disease. Comparing the high versus low tertile of FGCRS, the odds ratios (ORs) and 95% confidence intervals (CIs) were 1.26 (1.12 to 1.41) for all-cause dementia, 1.67 (1.33 to 2.09) for Alzheimer’s disease and 1.53 (1.07 to 2.16) for vascular dementia (all ptrend<0.05). Incident stroke and coronary heart disease accounted for 14% (95% CI: 9% to 21%) of the association between FGCRS and all-cause dementia. Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype. We observed an 83% (95% CI: 47% to 128%) higher all-cause dementia risk comparing the high–high versus low–low FGCRS–PRS category. For brain volumes, higher FGCRS was associated with greater log-transformed white matter hyperintensities, smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes. The association of cardiovascular risk burden with all-cause dementia is largely independent of CVD onset and genetic predisposition to dementia. |
| first_indexed | 2024-03-07T14:25:22Z |
| format | Article |
| id | doaj.art-94931b2da4004afa8c6803f7ddb4d1cf |
| institution | Directory Open Access Journal |
| issn | 2517-729X |
| language | English |
| last_indexed | 2024-03-07T14:25:22Z |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj.art-94931b2da4004afa8c6803f7ddb4d1cf2024-03-06T08:25:08ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-02-0137110.1136/gpsych-2023-101209Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK BiobankTing Li0Jing Chen1Yan Zheng2Klodian Dhana3Geng Zong4Yuan Ma5Trudy Voortman6Wei Gan7Yaying Cao8Yonghua Hu9Changzheng Yuan10Jie Shen11Gaohong Zhu12Chengwu Feng1313 First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China4 Neurology Department, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China14 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China9 Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA2 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China7 Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA10 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands5 Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK1 Department of Food Nutrition and Health, School of Medicine and Health, Harbin Institute of Technology, Harbin, Heilongjiang, China8 Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China12 School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China12 School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China3 Department of Nuclear Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China2 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, ChinaBackground Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure, while the role of genetics and incident cardiovascular disease (CVD) remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample, and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia (2006–2010, mean age 56.4 years) was conducted within the UK Biobank, with brain magnetic resonance imaging (MRI) measurement available for 15 104 participants since 2014. CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score (FGCRS). Dementia diagnosis was ascertained from inpatient and death register data.Results Over a median 12.0-year follow-up, 3998 all-cause dementia cases were identified. Higher FGCRS was associated with increased all-cause dementia risk after adjusting for demographic, major lifestyle, clinical factors and the polygenic risk score (PRS) of Alzheimer’s disease. Comparing the high versus low tertile of FGCRS, the odds ratios (ORs) and 95% confidence intervals (CIs) were 1.26 (1.12 to 1.41) for all-cause dementia, 1.67 (1.33 to 2.09) for Alzheimer’s disease and 1.53 (1.07 to 2.16) for vascular dementia (all ptrend<0.05). Incident stroke and coronary heart disease accounted for 14% (95% CI: 9% to 21%) of the association between FGCRS and all-cause dementia. Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype. We observed an 83% (95% CI: 47% to 128%) higher all-cause dementia risk comparing the high–high versus low–low FGCRS–PRS category. For brain volumes, higher FGCRS was associated with greater log-transformed white matter hyperintensities, smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes. The association of cardiovascular risk burden with all-cause dementia is largely independent of CVD onset and genetic predisposition to dementia.https://gpsych.bmj.com/content/37/1/e101209.full |
| spellingShingle | Ting Li Jing Chen Yan Zheng Klodian Dhana Geng Zong Yuan Ma Trudy Voortman Wei Gan Yaying Cao Yonghua Hu Changzheng Yuan Jie Shen Gaohong Zhu Chengwu Feng Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank General Psychiatry |
| title | Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank |
| title_full | Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank |
| title_fullStr | Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank |
| title_full_unstemmed | Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank |
| title_short | Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank |
| title_sort | cardiovascular risk burden dementia risk and brain structural imaging markers a study from uk biobank |
| url | https://gpsych.bmj.com/content/37/1/e101209.full |
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