Overview of microRNA-199a Regulation in Cancer
Qiwen Wang,1,2,* Bingyu Ye,1,2,* Ping Wang,1,2 Fenjie Yao,1,2 Chunyan Zhang,1,2 Guoying Yu1,2 1Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China; 2State Key Laboratory Cell Differ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-12-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/overview-of-microrna-199a-regulation-in-cancer-peer-reviewed-article-CMAR |
| _version_ | 1819035828102365184 |
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| author | Wang Q Ye B Wang P Yao F Zhang C Yu G |
| author_facet | Wang Q Ye B Wang P Yao F Zhang C Yu G |
| author_sort | Wang Q |
| collection | DOAJ |
| description | Qiwen Wang,1,2,* Bingyu Ye,1,2,* Ping Wang,1,2 Fenjie Yao,1,2 Chunyan Zhang,1,2 Guoying Yu1,2 1Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China; 2State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunyan Zhang; Guoying YuCollege of Life Science, Henan Normal University, 46# East of Construction Road, Xinxiang, Henan 453007, People’s Republic of ChinaTel +86 373 3325654; +86 373 3326001Fax +86 373 3326524Email zcy1119sdc@163.com; guoyingyu@htu.edu.cnAbstract: microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.Keywords: microRNA-199a, target genes, carcinoma, biomarker, regulatory mechanisms |
| first_indexed | 2024-12-21T07:55:49Z |
| format | Article |
| id | doaj.art-9494c5dd7626404184e2c7437b8b4421 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-21T07:55:49Z |
| publishDate | 2019-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-9494c5dd7626404184e2c7437b8b44212022-12-21T19:10:59ZengDove Medical PressCancer Management and Research1179-13222019-12-01Volume 11103271033550336Overview of microRNA-199a Regulation in CancerWang QYe BWang PYao FZhang CYu GQiwen Wang,1,2,* Bingyu Ye,1,2,* Ping Wang,1,2 Fenjie Yao,1,2 Chunyan Zhang,1,2 Guoying Yu1,2 1Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China; 2State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunyan Zhang; Guoying YuCollege of Life Science, Henan Normal University, 46# East of Construction Road, Xinxiang, Henan 453007, People’s Republic of ChinaTel +86 373 3325654; +86 373 3326001Fax +86 373 3326524Email zcy1119sdc@163.com; guoyingyu@htu.edu.cnAbstract: microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.Keywords: microRNA-199a, target genes, carcinoma, biomarker, regulatory mechanismshttps://www.dovepress.com/overview-of-microrna-199a-regulation-in-cancer-peer-reviewed-article-CMARmicrorna-199atarget genescarcinomabiomarkerregulatory mechanisms |
| spellingShingle | Wang Q Ye B Wang P Yao F Zhang C Yu G Overview of microRNA-199a Regulation in Cancer Cancer Management and Research microrna-199a target genes carcinoma biomarker regulatory mechanisms |
| title | Overview of microRNA-199a Regulation in Cancer |
| title_full | Overview of microRNA-199a Regulation in Cancer |
| title_fullStr | Overview of microRNA-199a Regulation in Cancer |
| title_full_unstemmed | Overview of microRNA-199a Regulation in Cancer |
| title_short | Overview of microRNA-199a Regulation in Cancer |
| title_sort | overview of microrna 199a regulation in cancer |
| topic | microrna-199a target genes carcinoma biomarker regulatory mechanisms |
| url | https://www.dovepress.com/overview-of-microrna-199a-regulation-in-cancer-peer-reviewed-article-CMAR |
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