The geography of the age at menopause in central Portugal since the early twentieth century
Abstract This work aims at studying the spatio-temporal evolution of the age at menopause in central Portugal since the early twentieth century. We analyzed $$N=320,444$$ N = 320 , 444 women that had already reached the menopause within a free breast cancer screening program between 1990 and 2018 an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25475-w |
| _version_ | 1797977419505729536 |
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| author | Rui Martins Bruno de Sousa Vítor Rodrigues |
| author_facet | Rui Martins Bruno de Sousa Vítor Rodrigues |
| author_sort | Rui Martins |
| collection | DOAJ |
| description | Abstract This work aims at studying the spatio-temporal evolution of the age at menopause in central Portugal since the early twentieth century. We analyzed $$N=320,444$$ N = 320 , 444 women that had already reached the menopause within a free breast cancer screening program between 1990 and 2018 and born in the period 1910–1960. One of the concerns was about early or late menopause thus we considered percentile regression to build the respective percentile curves inside the package GAMLSS in R. In order to capture the correlation at the regional level, a spatial random-effect was considered. The obtained clustered spatial effects were analyzed to assess geographical differences among the percentiles of the age at menopause by year of birth. An increasing trend in the median age at menopause and regional differences for all the considered percentiles were found. From 47.1 years in 1910 to 49.59 years in 1960 (about 2.49 years in 5 decades). Early and premature menopause (below percentile 5%) occur in the interior north (north-eastern). Late menopause (above percentile 95%) occur predominantly in the central-north and central-south areas. |
| first_indexed | 2024-04-11T05:07:39Z |
| format | Article |
| id | doaj.art-9494e28653dc4e7e84bc6ed41cb5755c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T05:07:39Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9494e28653dc4e7e84bc6ed41cb5755c2022-12-25T12:16:45ZengNature PortfolioScientific Reports2045-23222022-12-0112111210.1038/s41598-022-25475-wThe geography of the age at menopause in central Portugal since the early twentieth centuryRui Martins0Bruno de Sousa1Vítor Rodrigues2Departamento de Estatística e Investigação Operacional, Faculdade de Ciências, Universidade de LisboaFaculty of Psychology and Education Sciences (FPCE), Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), University of CoimbraFaculty of Medicine, University of CoimbraAbstract This work aims at studying the spatio-temporal evolution of the age at menopause in central Portugal since the early twentieth century. We analyzed $$N=320,444$$ N = 320 , 444 women that had already reached the menopause within a free breast cancer screening program between 1990 and 2018 and born in the period 1910–1960. One of the concerns was about early or late menopause thus we considered percentile regression to build the respective percentile curves inside the package GAMLSS in R. In order to capture the correlation at the regional level, a spatial random-effect was considered. The obtained clustered spatial effects were analyzed to assess geographical differences among the percentiles of the age at menopause by year of birth. An increasing trend in the median age at menopause and regional differences for all the considered percentiles were found. From 47.1 years in 1910 to 49.59 years in 1960 (about 2.49 years in 5 decades). Early and premature menopause (below percentile 5%) occur in the interior north (north-eastern). Late menopause (above percentile 95%) occur predominantly in the central-north and central-south areas.https://doi.org/10.1038/s41598-022-25475-w |
| spellingShingle | Rui Martins Bruno de Sousa Vítor Rodrigues The geography of the age at menopause in central Portugal since the early twentieth century Scientific Reports |
| title | The geography of the age at menopause in central Portugal since the early twentieth century |
| title_full | The geography of the age at menopause in central Portugal since the early twentieth century |
| title_fullStr | The geography of the age at menopause in central Portugal since the early twentieth century |
| title_full_unstemmed | The geography of the age at menopause in central Portugal since the early twentieth century |
| title_short | The geography of the age at menopause in central Portugal since the early twentieth century |
| title_sort | geography of the age at menopause in central portugal since the early twentieth century |
| url | https://doi.org/10.1038/s41598-022-25475-w |
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