B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection
B-1 cells can directly and indirectly influence the immune response. These cells are known to be excellent producers of natural antibodies and can secrete a variety of immunomodulatory molecules. They are also able to differentiate into B-1 cell-derived phagocytes (B-1CDP). B-1 cells can modulate ma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.01598/full |
| _version_ | 1819058348256919552 |
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| author | Raphael Francisco Dutra Barbosa da Rocha Isabel Ferreira LaRocque-de-Freitas Angelica Fernandes Arcanjo Jorgete Logullo Marise Pinheiro Nunes Celio Geraldo Freire-de-Lima Debora Decote-Ricardo |
| author_facet | Raphael Francisco Dutra Barbosa da Rocha Isabel Ferreira LaRocque-de-Freitas Angelica Fernandes Arcanjo Jorgete Logullo Marise Pinheiro Nunes Celio Geraldo Freire-de-Lima Debora Decote-Ricardo |
| author_sort | Raphael Francisco Dutra Barbosa da Rocha |
| collection | DOAJ |
| description | B-1 cells can directly and indirectly influence the immune response. These cells are known to be excellent producers of natural antibodies and can secrete a variety of immunomodulatory molecules. They are also able to differentiate into B-1 cell-derived phagocytes (B-1CDP). B-1 cells can modulate macrophages to become less effective, and B-1CDP cells are more susceptible in infection models. In this work, we investigated the microbicidal ability of these cells in Trypanosoma cruzi infection in vitro. The results show that macrophages from BALB/c mice are more susceptible to infection than macrophages from XID mice. The resistance observed in macrophages from XID mice was abolished in the presence of B-1 cells, and this event seems to be associated with IL-10 production by B-1 cells, which may have contributed to the decrease of NO production. Additionally, B-1CDP cells were more permissive to intracellular T. cruzi infection than peritoneal macrophages. These findings strongly suggest that B-1 cells and B-1CDP cells have a potential role in the persistence of the parasite in host cells. |
| first_indexed | 2024-12-21T13:53:46Z |
| format | Article |
| id | doaj.art-9497829a643f4a6b8c9959f0868e1851 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T13:53:46Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9497829a643f4a6b8c9959f0868e18512022-12-21T19:01:37ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-07-011010.3389/fmicb.2019.01598454437B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi InfectionRaphael Francisco Dutra Barbosa da Rocha0Isabel Ferreira LaRocque-de-Freitas1Angelica Fernandes Arcanjo2Jorgete Logullo3Marise Pinheiro Nunes4Celio Geraldo Freire-de-Lima5Debora Decote-Ricardo6Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, BrazilB-1 cells can directly and indirectly influence the immune response. These cells are known to be excellent producers of natural antibodies and can secrete a variety of immunomodulatory molecules. They are also able to differentiate into B-1 cell-derived phagocytes (B-1CDP). B-1 cells can modulate macrophages to become less effective, and B-1CDP cells are more susceptible in infection models. In this work, we investigated the microbicidal ability of these cells in Trypanosoma cruzi infection in vitro. The results show that macrophages from BALB/c mice are more susceptible to infection than macrophages from XID mice. The resistance observed in macrophages from XID mice was abolished in the presence of B-1 cells, and this event seems to be associated with IL-10 production by B-1 cells, which may have contributed to the decrease of NO production. Additionally, B-1CDP cells were more permissive to intracellular T. cruzi infection than peritoneal macrophages. These findings strongly suggest that B-1 cells and B-1CDP cells have a potential role in the persistence of the parasite in host cells.https://www.frontiersin.org/article/10.3389/fmicb.2019.01598/fullB-1 cellsB-1CDP cellsTrypanosoma cruzimacrophagessusceptibility |
| spellingShingle | Raphael Francisco Dutra Barbosa da Rocha Isabel Ferreira LaRocque-de-Freitas Angelica Fernandes Arcanjo Jorgete Logullo Marise Pinheiro Nunes Celio Geraldo Freire-de-Lima Debora Decote-Ricardo B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection Frontiers in Microbiology B-1 cells B-1CDP cells Trypanosoma cruzi macrophages susceptibility |
| title | B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection |
| title_full | B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection |
| title_fullStr | B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection |
| title_full_unstemmed | B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection |
| title_short | B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection |
| title_sort | b 1 cells may drive macrophages susceptibility to trypanosoma cruzi infection |
| topic | B-1 cells B-1CDP cells Trypanosoma cruzi macrophages susceptibility |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.01598/full |
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