Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Background/Aims We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Methods This study enrolled 169 patients who underwent serum NGAL testing at CRRT in...
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| Language: | English |
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The Korean Association of Internal Medicine
2021-03-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-446.pdf |
| _version_ | 1818607823106342912 |
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| author | Yohan Park Tae Hyun Ban Hyung Duk Kim Eun Jeong Ko Jongmin Lee Seok Chan Kim Cheol Whee Park Chul Woo Yang Yong-Soo Kim Byung Ha Chung |
| author_facet | Yohan Park Tae Hyun Ban Hyung Duk Kim Eun Jeong Ko Jongmin Lee Seok Chan Kim Cheol Whee Park Chul Woo Yang Yong-Soo Kim Byung Ha Chung |
| author_sort | Yohan Park |
| collection | DOAJ |
| description | Background/Aims We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Methods This study enrolled 169 patients who underwent serum NGAL testing at CRRT initiation from June 2017 to January 2019. The predictive power of serum NGAL level for 28-day mortality was compared to the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score and Sequential Organ Failure Assessment (SOFA) score via area under the receiver operating characteristic curve (AuROC) value. Results There were 55 survivors and 114 non-survivors at 28 days post-CRRT initiation. Median serum NGAL level was significantly higher in the non-survivor group than in the survivor group (743.0 ng/mL vs. 504.0 ng/mL, p = 0.003). The AuROC value of serum NGAL level was 0.640, which was lower than APACHE-II score and SOFA score values (0.767 and 0.715, respectively). However, in the low APACHE-II score group (< 27.5), AuROC value of serum NGAL was significantly increased (0.698), and it was an independent risk factor for 28 day-mortality (hazard ratio, 2.405; 95% confidence interval, 1.209 to 4.783; p = 0.012). Conclusions In patients with AKI requiring CRRT, serum NGAL levels may be useful for predicting short-term mortality in those with low APACHE-II scores. |
| first_indexed | 2024-12-16T14:32:52Z |
| format | Article |
| id | doaj.art-949975b949dc4c9396a10ef2035a61c8 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-16T14:32:52Z |
| publishDate | 2021-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-949975b949dc4c9396a10ef2035a61c82022-12-21T22:28:11ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-03-0136239240010.3904/kjim.2019.446170421Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapyYohan Park0Tae Hyun Ban1Hyung Duk Kim2Eun Jeong Ko3Jongmin Lee4Seok Chan Kim5Cheol Whee Park6Chul Woo Yang7Yong-Soo Kim8Byung Ha Chung9 Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Methods This study enrolled 169 patients who underwent serum NGAL testing at CRRT initiation from June 2017 to January 2019. The predictive power of serum NGAL level for 28-day mortality was compared to the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score and Sequential Organ Failure Assessment (SOFA) score via area under the receiver operating characteristic curve (AuROC) value. Results There were 55 survivors and 114 non-survivors at 28 days post-CRRT initiation. Median serum NGAL level was significantly higher in the non-survivor group than in the survivor group (743.0 ng/mL vs. 504.0 ng/mL, p = 0.003). The AuROC value of serum NGAL level was 0.640, which was lower than APACHE-II score and SOFA score values (0.767 and 0.715, respectively). However, in the low APACHE-II score group (< 27.5), AuROC value of serum NGAL was significantly increased (0.698), and it was an independent risk factor for 28 day-mortality (hazard ratio, 2.405; 95% confidence interval, 1.209 to 4.783; p = 0.012). Conclusions In patients with AKI requiring CRRT, serum NGAL levels may be useful for predicting short-term mortality in those with low APACHE-II scores.http://www.kjim.org/upload/pdf/kjim-2019-446.pdfneutrophil gelatinase-associated lipocalincritical illnessacute kidney injuryrenal replacement therapymortality |
| spellingShingle | Yohan Park Tae Hyun Ban Hyung Duk Kim Eun Jeong Ko Jongmin Lee Seok Chan Kim Cheol Whee Park Chul Woo Yang Yong-Soo Kim Byung Ha Chung Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy The Korean Journal of Internal Medicine neutrophil gelatinase-associated lipocalin critical illness acute kidney injury renal replacement therapy mortality |
| title | Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy |
| title_full | Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy |
| title_fullStr | Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy |
| title_full_unstemmed | Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy |
| title_short | Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy |
| title_sort | mortality prediction of serum neutrophil gelatinase associated lipocalin in patients requiring continuous renal replacement therapy |
| topic | neutrophil gelatinase-associated lipocalin critical illness acute kidney injury renal replacement therapy mortality |
| url | http://www.kjim.org/upload/pdf/kjim-2019-446.pdf |
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