Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report
Acrodermatitis continua of Hallopeau is a rare variant of localized pustular psoriasis characterized by the recurrent eruption of sterile pustules involving the distal portions of the fingers and toes that can lead to the destruction of the nail apparatus. Acrodermatitis continua of Hallopeau is a c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-03-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X231160937 |
| _version_ | 1797865896176254976 |
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| author | Katrina D Cirone Fiona E Lovegrove |
| author_facet | Katrina D Cirone Fiona E Lovegrove |
| author_sort | Katrina D Cirone |
| collection | DOAJ |
| description | Acrodermatitis continua of Hallopeau is a rare variant of localized pustular psoriasis characterized by the recurrent eruption of sterile pustules involving the distal portions of the fingers and toes that can lead to the destruction of the nail apparatus. Acrodermatitis continua of Hallopeau is a chronic, relapsing condition that is resistant to most topical and systemic psoriasis therapies, making it notoriously difficult to manage. Interleukin-36 and interleukin-17 are thought to play a pivotal role in the pathophysiology of pustular psoriasis, and evidence suggests that interleukin-17 inhibition can be an effective therapy for pustular psoriasis variants, including acrodermatitis continua of Hallopeau. Bimekizumab, a monoclonal antibody that inhibits the interleukin-17 pathway, may be a safe and effective treatment option for patients with acrodermatitis continua of Hallopeau. We present the first documented case of a patient with acrodermatitis continua of Hallopeau of the bilateral thumbnails who experienced an excellent response to bimekizumab treatment. |
| first_indexed | 2024-04-09T23:16:35Z |
| format | Article |
| id | doaj.art-949a251dee0c4a94a0bfb96c255f7904 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-04-09T23:16:35Z |
| publishDate | 2023-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-949a251dee0c4a94a0bfb96c255f79042023-03-22T08:03:19ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2023-03-011110.1177/2050313X231160937Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case reportKatrina D Cirone0Fiona E Lovegrove1Schulich School of Medicine & Dentistry, Western University, London, ON, CanadaLovegrove Dermatology, London, ON, CanadaAcrodermatitis continua of Hallopeau is a rare variant of localized pustular psoriasis characterized by the recurrent eruption of sterile pustules involving the distal portions of the fingers and toes that can lead to the destruction of the nail apparatus. Acrodermatitis continua of Hallopeau is a chronic, relapsing condition that is resistant to most topical and systemic psoriasis therapies, making it notoriously difficult to manage. Interleukin-36 and interleukin-17 are thought to play a pivotal role in the pathophysiology of pustular psoriasis, and evidence suggests that interleukin-17 inhibition can be an effective therapy for pustular psoriasis variants, including acrodermatitis continua of Hallopeau. Bimekizumab, a monoclonal antibody that inhibits the interleukin-17 pathway, may be a safe and effective treatment option for patients with acrodermatitis continua of Hallopeau. We present the first documented case of a patient with acrodermatitis continua of Hallopeau of the bilateral thumbnails who experienced an excellent response to bimekizumab treatment.https://doi.org/10.1177/2050313X231160937 |
| spellingShingle | Katrina D Cirone Fiona E Lovegrove Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report SAGE Open Medical Case Reports |
| title | Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report |
| title_full | Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report |
| title_fullStr | Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report |
| title_full_unstemmed | Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report |
| title_short | Acrodermatitis continua of Hallopeau successfully treated with bimekizumab: A case report |
| title_sort | acrodermatitis continua of hallopeau successfully treated with bimekizumab a case report |
| url | https://doi.org/10.1177/2050313X231160937 |
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