Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Specific Monoclonal Antibody and Recombinant F(ab)

Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Specific Monoclonal Antibody and Recombinant F(ab)

Smokeless tobacco products have been associated with increased risks of oro-pharyngeal cancers, due in part to the presence of tobacco-specific nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). These potent carcinogens are formed during tobacco curing and as a result...

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Bibliographic Details
Main Authors: Lawrence K. Silbart, Michael A. Lynes, Gregory P. Marusov, John Zinckgraf, Stewart K. Richardson, Debra Rood, Daniel I. Zapata, Amy R. Howell, Tolga Barker, Heather Wanczyk
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Toxins
Subjects:
TSNAs
F(ab)
NNK
monoclonal antibody
2A cleavage
Online Access:http://www.mdpi.com/2072-6651/5/3/568

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