The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts
Wolbachia is an intracellular alpha-proteobacterium which is transmitted vertically from mother to offspring but also frequently switches horizontally from one host to another. Our hypothesis is based on the role of immune cells and the organs that produce them, the Hematopoietic Organs (HOs), as pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01424/full |
| _version_ | 1818277451022729216 |
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| author | Christine eBraquart-Varnier Maryline eRaimond Gaetan eMappa Frederic eChevalier Winka eLe Clec'h Mathieu eSicard |
| author_facet | Christine eBraquart-Varnier Maryline eRaimond Gaetan eMappa Frederic eChevalier Winka eLe Clec'h Mathieu eSicard |
| author_sort | Christine eBraquart-Varnier |
| collection | DOAJ |
| description | Wolbachia is an intracellular alpha-proteobacterium which is transmitted vertically from mother to offspring but also frequently switches horizontally from one host to another. Our hypothesis is based on the role of immune cells and the organs that produce them, the Hematopoietic Organs (HOs), as primordial niches for the propagation of Wolbachia via hemocytes both (i) within hosts: to initiate and maintain the systemic infection and (ii) between hosts: to promote both vertical and horizontal transmission of Wolbachia. Therefore, we review some fundamental ideas underlying this hypothesis and go further with new empirical data that lead to a first close-up analysis of the potential role of HOs in Wolbachia propagation. The monitoring of the first steps of Wolbachia infection in horizontally infected host organs by TEM and qPCR suggests that (i) HOs are colonized early and extensively as soon as they are in contact with Wolbachia which find in these cells a favorable niche to multiply and (ii) infected HOs which expel hemocytes all lifelong can generate and maintain a systemic infection that could contribute to increase both vertical and horizontal propagation of these symbionts. |
| first_indexed | 2024-12-12T23:01:45Z |
| format | Article |
| id | doaj.art-949b97adaa434f7c8f5dddff32a43355 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T23:01:45Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-949b97adaa434f7c8f5dddff32a433552022-12-22T00:08:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-12-01610.3389/fmicb.2015.01424157210The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hostsChristine eBraquart-Varnier0Maryline eRaimond1Gaetan eMappa2Frederic eChevalier3Winka eLe Clec'h4Mathieu eSicard5Université de PoitiersUniversité de PoitiersUniversité de PoitiersTexas Biomedical Research InstituteTexas Biomedical Research InstituteUniversité de MontpellierWolbachia is an intracellular alpha-proteobacterium which is transmitted vertically from mother to offspring but also frequently switches horizontally from one host to another. Our hypothesis is based on the role of immune cells and the organs that produce them, the Hematopoietic Organs (HOs), as primordial niches for the propagation of Wolbachia via hemocytes both (i) within hosts: to initiate and maintain the systemic infection and (ii) between hosts: to promote both vertical and horizontal transmission of Wolbachia. Therefore, we review some fundamental ideas underlying this hypothesis and go further with new empirical data that lead to a first close-up analysis of the potential role of HOs in Wolbachia propagation. The monitoring of the first steps of Wolbachia infection in horizontally infected host organs by TEM and qPCR suggests that (i) HOs are colonized early and extensively as soon as they are in contact with Wolbachia which find in these cells a favorable niche to multiply and (ii) infected HOs which expel hemocytes all lifelong can generate and maintain a systemic infection that could contribute to increase both vertical and horizontal propagation of these symbionts.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01424/fullHematopoietic SystemHemocytesSymbiosisWolbachiaTerrestrial isopodsintracellular symbionts |
| spellingShingle | Christine eBraquart-Varnier Maryline eRaimond Gaetan eMappa Frederic eChevalier Winka eLe Clec'h Mathieu eSicard The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts Frontiers in Microbiology Hematopoietic System Hemocytes Symbiosis Wolbachia Terrestrial isopods intracellular symbionts |
| title | The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts |
| title_full | The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts |
| title_fullStr | The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts |
| title_full_unstemmed | The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts |
| title_short | The hematopoietic organ: a cornerstone for Wolbachia propagation between and within hosts |
| title_sort | hematopoietic organ a cornerstone for wolbachia propagation between and within hosts |
| topic | Hematopoietic System Hemocytes Symbiosis Wolbachia Terrestrial isopods intracellular symbionts |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01424/full |
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