Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy

Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy

Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve degeneration and serious neuropathic pain termed paclitaxel-induced peripheral neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do not eliminate PIPN, and no therapies are avail...

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Bibliographic Details
Main Authors: Zizhen Wu, Gabor Toro, Guoying Xu, Danny Dang, Charmaine Prater, Qing Yang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
KCNQ channels
DRG
paclitaxel
pain
neuropathy
Online Access:https://www.mdpi.com/2073-4409/11/24/4067

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