ASNS can predict the poor prognosis of clear cell renal cell carcinoma
PurposeClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies of the urinary system. This study was conducted to discover a new target that can predict the prognosis and promote the treatment of ccRCC.MethodsThe raw data were downloaded from the TCGA database, and the predict...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.882888/full |
| _version_ | 1811215196633432064 |
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| author | Xinqiang Gan Xinqiang Gan Ruiji Liu Hong Cheng Weipu Mao Ninghan Feng Ming Chen Ming Chen |
| author_facet | Xinqiang Gan Xinqiang Gan Ruiji Liu Hong Cheng Weipu Mao Ninghan Feng Ming Chen Ming Chen |
| author_sort | Xinqiang Gan |
| collection | DOAJ |
| description | PurposeClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies of the urinary system. This study was conducted to discover a new target that can predict the prognosis and promote the treatment of ccRCC.MethodsThe raw data were downloaded from the TCGA database, and the predictive value of ASNS for various clinicopathological features was verified in the following analysis. Then, we analyzed the potential involvement of ASNS in tumor immunity and obtained the possible pathways involving ASNS through GO/KEGG enrichment analysis and GSEA. We also further verified our findings in pathological specimens of ccRCC patients.ResultsASNS expression was significantly increased in ccRCC, which was associated with advanced clinicopathological characteristics. It was an independent prognostic factor for overall survival in 535 patients with ccRCC. Immune cell infiltration analysis revealed that ASNS expression was related to T lymphocyte infiltration of tumors and poor prognosis. Moreover, we performed relevant functional enrichment analyses of ASNS.ConclusionsASNS might play a significant role in the development and immune cell infiltration of ccRCC and serve as a valuable clinical prognostic biomarker. |
| first_indexed | 2024-04-12T06:18:15Z |
| format | Article |
| id | doaj.art-949c974904d649e8a9a54cc99aa17368 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T06:18:15Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-949c974904d649e8a9a54cc99aa173682022-12-22T03:44:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.882888882888ASNS can predict the poor prognosis of clear cell renal cell carcinomaXinqiang Gan0Xinqiang Gan1Ruiji Liu2Hong Cheng3Weipu Mao4Ninghan Feng5Ming Chen6Ming Chen7Department of Urology, People’s Hospital of Putuo District, Shanghai, ChinaDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, ChinaDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, ChinaDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, ChinaDepartment of Urology, People’s Hospital of Putuo District, Shanghai, ChinaDepartment of Urology, Wuxi No.2 Hospital, Nanjing Medical University, Wuxi, ChinaDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, ChinaNanjing Lishui District People’s Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, ChinaPurposeClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies of the urinary system. This study was conducted to discover a new target that can predict the prognosis and promote the treatment of ccRCC.MethodsThe raw data were downloaded from the TCGA database, and the predictive value of ASNS for various clinicopathological features was verified in the following analysis. Then, we analyzed the potential involvement of ASNS in tumor immunity and obtained the possible pathways involving ASNS through GO/KEGG enrichment analysis and GSEA. We also further verified our findings in pathological specimens of ccRCC patients.ResultsASNS expression was significantly increased in ccRCC, which was associated with advanced clinicopathological characteristics. It was an independent prognostic factor for overall survival in 535 patients with ccRCC. Immune cell infiltration analysis revealed that ASNS expression was related to T lymphocyte infiltration of tumors and poor prognosis. Moreover, we performed relevant functional enrichment analyses of ASNS.ConclusionsASNS might play a significant role in the development and immune cell infiltration of ccRCC and serve as a valuable clinical prognostic biomarker.https://www.frontiersin.org/articles/10.3389/fonc.2022.882888/fullclear cell renal cell carcinomaasparagine synthasetumor microenvironmentimmune infiltrationprognosis |
| spellingShingle | Xinqiang Gan Xinqiang Gan Ruiji Liu Hong Cheng Weipu Mao Ninghan Feng Ming Chen Ming Chen ASNS can predict the poor prognosis of clear cell renal cell carcinoma Frontiers in Oncology clear cell renal cell carcinoma asparagine synthase tumor microenvironment immune infiltration prognosis |
| title | ASNS can predict the poor prognosis of clear cell renal cell carcinoma |
| title_full | ASNS can predict the poor prognosis of clear cell renal cell carcinoma |
| title_fullStr | ASNS can predict the poor prognosis of clear cell renal cell carcinoma |
| title_full_unstemmed | ASNS can predict the poor prognosis of clear cell renal cell carcinoma |
| title_short | ASNS can predict the poor prognosis of clear cell renal cell carcinoma |
| title_sort | asns can predict the poor prognosis of clear cell renal cell carcinoma |
| topic | clear cell renal cell carcinoma asparagine synthase tumor microenvironment immune infiltration prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.882888/full |
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