Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis
Aim: The aim of our study was to investigate the importance of oxidative stress levels in the diagnosis and prognosis of acute pancreatitis.Materials and Methods: In total, 55 patients with acute pancreatitis and 47 healthy volunteers were included in the study. The study group was divided into thre...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2018-06-01
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| Series: | Eurasian Journal of Emergency Medicine |
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http://akademikaciltip.com/archives/archive-detail/article-preview/oxidative-stress-parameters-in-predicting-the-seve/21553
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| author | Bulent Demir Havva Sahin Kavakli Ferhat Icme Alp Sener Gul Pamukcu Gunaydin Gulhan Kurtoglu Celik |
| author_facet | Bulent Demir Havva Sahin Kavakli Ferhat Icme Alp Sener Gul Pamukcu Gunaydin Gulhan Kurtoglu Celik |
| author_sort | Bulent Demir |
| collection | DOAJ |
| description | Aim: The aim of our study was to investigate the importance of oxidative stress levels in the diagnosis and prognosis of acute pancreatitis.Materials and Methods: In total, 55 patients with acute pancreatitis and 47 healthy volunteers were included in the study. The study group was divided into three subgroups according to the computed tomography (CT) severity index. Group 1 consisted of patients with CT severity index score of 0-2, Group 2 consisted of patients with CT severity index of 3-6, and Group 3 consisted of patients with CT severity index 7-10. Total oxidant stress (TOS), total antioxidant stress (TAS), and oxidative stress index (OSI) were compared between study and control groups.Results: The mean age of the patients in the study group was significantly higher compared to the control group (p<0.001). No significant difference was found between groups in terms of sex (p=0.999). TOS (p<0.001), TAS (p<0.011), and OSI (p<0.001) levels were significantly higher in the study group compared to the control group. No significant difference was found between subgroups of the study group (Group 1-good prognosis, Group 2-moderate prognosis, Group 3-poor prognosis) with respect to TOS (p=0.844), TAS (p=0.600), and OSI (p=0.846) levels.Conclusion: Although our study does not support the use of oxidative stress parameters for the prediction of the severity and prognosis in patients with acute pancreatitis, additional and larger studies are warranted. |
| first_indexed | 2024-04-10T12:31:00Z |
| format | Article |
| id | doaj.art-949cd191ce50440abb7df4341eb348c2 |
| institution | Directory Open Access Journal |
| issn | 2149-5807 2149-6048 |
| language | English |
| last_indexed | 2024-04-10T12:31:00Z |
| publishDate | 2018-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Eurasian Journal of Emergency Medicine |
| spelling | doaj.art-949cd191ce50440abb7df4341eb348c22023-02-15T16:14:54ZengGalenos YayineviEurasian Journal of Emergency Medicine2149-58072149-60482018-06-01172555810.5152/eajem.2018.5526413049054Oxidative Stress Parameters in Predicting the Severity of Acute PancreatitisBulent Demir0Havva Sahin Kavakli1Ferhat Icme2Alp Sener3Gul Pamukcu Gunaydin4Gulhan Kurtoglu Celik5 Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey Department of Emergency Medicine, Yildirim Beyazit University School of Medicine, Ankara, Turkey Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey Department of Emergency Medicine, Yildirim Beyazit University School of Medicine, Ankara, Turkey Aim: The aim of our study was to investigate the importance of oxidative stress levels in the diagnosis and prognosis of acute pancreatitis.Materials and Methods: In total, 55 patients with acute pancreatitis and 47 healthy volunteers were included in the study. The study group was divided into three subgroups according to the computed tomography (CT) severity index. Group 1 consisted of patients with CT severity index score of 0-2, Group 2 consisted of patients with CT severity index of 3-6, and Group 3 consisted of patients with CT severity index 7-10. Total oxidant stress (TOS), total antioxidant stress (TAS), and oxidative stress index (OSI) were compared between study and control groups.Results: The mean age of the patients in the study group was significantly higher compared to the control group (p<0.001). No significant difference was found between groups in terms of sex (p=0.999). TOS (p<0.001), TAS (p<0.011), and OSI (p<0.001) levels were significantly higher in the study group compared to the control group. No significant difference was found between subgroups of the study group (Group 1-good prognosis, Group 2-moderate prognosis, Group 3-poor prognosis) with respect to TOS (p=0.844), TAS (p=0.600), and OSI (p=0.846) levels.Conclusion: Although our study does not support the use of oxidative stress parameters for the prediction of the severity and prognosis in patients with acute pancreatitis, additional and larger studies are warranted. http://akademikaciltip.com/archives/archive-detail/article-preview/oxidative-stress-parameters-in-predicting-the-seve/21553 Pancreatitisoxidative stressprognosisdiagnosis |
| spellingShingle | Bulent Demir Havva Sahin Kavakli Ferhat Icme Alp Sener Gul Pamukcu Gunaydin Gulhan Kurtoglu Celik Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis Eurasian Journal of Emergency Medicine Pancreatitis oxidative stress prognosis diagnosis |
| title | Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis |
| title_full | Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis |
| title_fullStr | Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis |
| title_full_unstemmed | Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis |
| title_short | Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis |
| title_sort | oxidative stress parameters in predicting the severity of acute pancreatitis |
| topic | Pancreatitis oxidative stress prognosis diagnosis |
| url |
http://akademikaciltip.com/archives/archive-detail/article-preview/oxidative-stress-parameters-in-predicting-the-seve/21553
|
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