Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index
Background Upstroke time is the transit time from the nadir to peak of the waveform of pulse volume recording. The purpose of this study was to determine whether upstroke time at the ankle is a useful vascular marker for detecting patients with advanced atherosclerosis in combination with ankle‐brac...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.017139 |
| _version_ | 1818328003490349056 |
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| author | Tatsuya Maruhashi Masato Kajikawa Shinji Kishimoto Haruki Hashimoto Yuji Takaeko Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Yoshiki Aibara Farina Muhamad Yusoff Takayuki Hidaka Kazuaki Chayama Ayumu Nakashima Chikara Goto Yasuki Kihara Yukihito Higashi |
| author_facet | Tatsuya Maruhashi Masato Kajikawa Shinji Kishimoto Haruki Hashimoto Yuji Takaeko Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Yoshiki Aibara Farina Muhamad Yusoff Takayuki Hidaka Kazuaki Chayama Ayumu Nakashima Chikara Goto Yasuki Kihara Yukihito Higashi |
| author_sort | Tatsuya Maruhashi |
| collection | DOAJ |
| description | Background Upstroke time is the transit time from the nadir to peak of the waveform of pulse volume recording. The purpose of this study was to determine whether upstroke time at the ankle is a useful vascular marker for detecting patients with advanced atherosclerosis in combination with ankle‐brachial index (ABI). Methods and Results We measured upstroke time and ABI in 2313 subjects (mean age, 61.2±15.3 years). The prevalence of coronary artery disease (CAD) was significantly higher in patients with prolonged upstroke time (≥180 ms) than in subjects with normal upstroke time (<180 ms) (29.6% versus 11.8%; P<0.001), with a significant association between prolonged upstroke time and an increased risk of CAD (odds ratio [OR], 1.61; 95% CI, 1.07–2.44; P=0.02). In 1954 subjects with normal ABI (1.00 ≤ ABI ≤ 1.40), the prevalence of CAD was significantly higher in patients with prolonged upstroke time than in subjects with normal upstroke time (29.5% versus 10.6%; P<0.001), with a significant association between prolonged upstroke time and CAD (OR, 2.33; 95% CI, 1.41–3.87; P=0.001), whereas there was no significant association between upstroke time and CAD in subjects with low ABI (<1.00) (OR, 1.24; 95% CI, 0.72–2.16; P=0.44). Conclusions Upstroke time may be a useful vascular marker for detecting patients with CAD, especially in subjects with normal ABI who are usually considered not to have advanced atherosclerosis by ABI measurement alone. More attention should be paid to upstroke time for detecting patients with advanced atherosclerosis. Registration URL: https://www.umin.ac.jp; Unique identifier: UMIN000039512. |
| first_indexed | 2024-12-13T12:25:15Z |
| format | Article |
| id | doaj.art-949d2b1ab00241d89420dd5f8242b9fb |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:25:15Z |
| publishDate | 2020-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-949d2b1ab00241d89420dd5f8242b9fb2022-12-21T23:46:22ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-12-0192310.1161/JAHA.120.017139Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial IndexTatsuya Maruhashi0Masato Kajikawa1Shinji Kishimoto2Haruki Hashimoto3Yuji Takaeko4Takayuki Yamaji5Takahiro Harada6Yu Hashimoto7Yiming Han8Yoshiki Aibara9Farina Muhamad Yusoff10Takayuki Hidaka11Kazuaki Chayama12Ayumu Nakashima13Chikara Goto14Yasuki Kihara15Yukihito Higashi16Department of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDivision of Regeneration and Medicine Hiroshima University Hospital Hiroshima JapanDepartment of Cardiovascular Regeneration and Medicine Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Cardiovascular Regeneration and Medicine Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima JapanDepartment of Cardiovascular Regeneration and Medicine Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima JapanDepartment of Cardiovascular Regeneration and Medicine Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical SciencesHiroshima University Hiroshima JapanDepartment of Stem Cell Biology and Medicine Graduate School of Biomedical and Sciences Hiroshima University Hiroshima JapanDepartment of Rehabilitation Faculty of General Rehabilitation Hiroshima International University Hiroshima JapanDepartment of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDivision of Regeneration and Medicine Hiroshima University Hospital Hiroshima JapanBackground Upstroke time is the transit time from the nadir to peak of the waveform of pulse volume recording. The purpose of this study was to determine whether upstroke time at the ankle is a useful vascular marker for detecting patients with advanced atherosclerosis in combination with ankle‐brachial index (ABI). Methods and Results We measured upstroke time and ABI in 2313 subjects (mean age, 61.2±15.3 years). The prevalence of coronary artery disease (CAD) was significantly higher in patients with prolonged upstroke time (≥180 ms) than in subjects with normal upstroke time (<180 ms) (29.6% versus 11.8%; P<0.001), with a significant association between prolonged upstroke time and an increased risk of CAD (odds ratio [OR], 1.61; 95% CI, 1.07–2.44; P=0.02). In 1954 subjects with normal ABI (1.00 ≤ ABI ≤ 1.40), the prevalence of CAD was significantly higher in patients with prolonged upstroke time than in subjects with normal upstroke time (29.5% versus 10.6%; P<0.001), with a significant association between prolonged upstroke time and CAD (OR, 2.33; 95% CI, 1.41–3.87; P=0.001), whereas there was no significant association between upstroke time and CAD in subjects with low ABI (<1.00) (OR, 1.24; 95% CI, 0.72–2.16; P=0.44). Conclusions Upstroke time may be a useful vascular marker for detecting patients with CAD, especially in subjects with normal ABI who are usually considered not to have advanced atherosclerosis by ABI measurement alone. More attention should be paid to upstroke time for detecting patients with advanced atherosclerosis. Registration URL: https://www.umin.ac.jp; Unique identifier: UMIN000039512.https://www.ahajournals.org/doi/10.1161/JAHA.120.017139atherosclerosisbiomarkercoronary artery disease |
| spellingShingle | Tatsuya Maruhashi Masato Kajikawa Shinji Kishimoto Haruki Hashimoto Yuji Takaeko Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Yoshiki Aibara Farina Muhamad Yusoff Takayuki Hidaka Kazuaki Chayama Ayumu Nakashima Chikara Goto Yasuki Kihara Yukihito Higashi Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis biomarker coronary artery disease |
| title | Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index |
| title_full | Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index |
| title_fullStr | Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index |
| title_full_unstemmed | Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index |
| title_short | Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle‐Brachial Index |
| title_sort | upstroke time is a useful vascular marker for detecting patients with coronary artery disease among subjects with normal ankle brachial index |
| topic | atherosclerosis biomarker coronary artery disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.017139 |
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