Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influenc...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/8061 |
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| author | Sonia Calabrò Svenja Kankowski Matilde Cescon Giovanna Gambarotta Stefania Raimondo Kirsten Haastert-Talini Giulia Ronchi |
| author_facet | Sonia Calabrò Svenja Kankowski Matilde Cescon Giovanna Gambarotta Stefania Raimondo Kirsten Haastert-Talini Giulia Ronchi |
| author_sort | Sonia Calabrò |
| collection | DOAJ |
| description | It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions. |
| first_indexed | 2024-03-11T04:17:16Z |
| format | Article |
| id | doaj.art-949d59b723f14555a244ae9e85c767ae |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:17:16Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-949d59b723f14555a244ae9e85c767ae2023-11-17T23:04:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249806110.3390/ijms24098061Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological ConditionsSonia Calabrò0Svenja Kankowski1Matilde Cescon2Giovanna Gambarotta3Stefania Raimondo4Kirsten Haastert-Talini5Giulia Ronchi6Department of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, ItalyHannover Medical School, Institute of Neuroanatomy and Cell Biology, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyDepartment of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, ItalyDepartment of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 10, Orbassano, 10043 Torino, ItalyDepartment of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 10, Orbassano, 10043 Torino, ItalyHannover Medical School, Institute of Neuroanatomy and Cell Biology, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyDepartment of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 10, Orbassano, 10043 Torino, ItalyIt has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions.https://www.mdpi.com/1422-0067/24/9/8061gut microbiotaperipheral nervenerve injury and regenerationshort chain fatty acid |
| spellingShingle | Sonia Calabrò Svenja Kankowski Matilde Cescon Giovanna Gambarotta Stefania Raimondo Kirsten Haastert-Talini Giulia Ronchi Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions International Journal of Molecular Sciences gut microbiota peripheral nerve nerve injury and regeneration short chain fatty acid |
| title | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
| title_full | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
| title_fullStr | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
| title_full_unstemmed | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
| title_short | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
| title_sort | impact of gut microbiota on the peripheral nervous system in physiological regenerative and pathological conditions |
| topic | gut microbiota peripheral nerve nerve injury and regeneration short chain fatty acid |
| url | https://www.mdpi.com/1422-0067/24/9/8061 |
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