Central pontine myelinolysis after liver transplant: A case report and an updated review
Based on brain magnetic resonance imaging results, the second and third most frequent causes of central pontine myelinolysis (CPM) were liver transplant (LT) and cirrhosis, which together accounted for 13.7% and 12.5% of all diagnoses of CPM. Medical diseases including cirrhosis, LT, malnutrition, a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2023;volume=17;issue=2;spage=275;epage=277;aulast=Biagio |
| _version_ | 1797866374213664768 |
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| author | Francisco Biagio Murta e Di Flora Maurício Vitor Machado Oliveira Pedro Henrique Torres Menezes Marina Ayres Delgado |
| author_facet | Francisco Biagio Murta e Di Flora Maurício Vitor Machado Oliveira Pedro Henrique Torres Menezes Marina Ayres Delgado |
| author_sort | Francisco Biagio Murta e Di Flora |
| collection | DOAJ |
| description | Based on brain magnetic resonance imaging results, the second and third most frequent causes of central pontine myelinolysis (CPM) were liver transplant (LT) and cirrhosis, which together accounted for 13.7% and 12.5% of all diagnoses of CPM. Medical diseases including cirrhosis, LT, malnutrition, and alcoholism are well-known conditions associated with CPM in addition to hyponatremia. The prognosis is poor and depends on early diagnosis and treatment to achieve better outcomes. This is a case report of CPM occurring after a deceased donor LT in a patient presenting many risk factors such as chronic hyponatremia, previous episodes of encephalopathy, and tacrolimus immunosuppression. We briefly discuss the pathophysiology, risk factors, diagnosis, and treatment, highlighting the role and challenges of the anesthesiologist in managing this kind of patient and preventing the syndrome in the context of major surgery. |
| first_indexed | 2024-04-09T23:24:17Z |
| format | Article |
| id | doaj.art-94a1b48538eb453da700bb480d7cdb14 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-04-09T23:24:17Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-94a1b48538eb453da700bb480d7cdb142023-03-21T11:26:55ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2023-01-0117227527710.4103/sja.sja_709_22Central pontine myelinolysis after liver transplant: A case report and an updated reviewFrancisco Biagio Murta e Di FloraMaurício Vitor Machado OliveiraPedro Henrique Torres MenezesMarina Ayres DelgadoBased on brain magnetic resonance imaging results, the second and third most frequent causes of central pontine myelinolysis (CPM) were liver transplant (LT) and cirrhosis, which together accounted for 13.7% and 12.5% of all diagnoses of CPM. Medical diseases including cirrhosis, LT, malnutrition, and alcoholism are well-known conditions associated with CPM in addition to hyponatremia. The prognosis is poor and depends on early diagnosis and treatment to achieve better outcomes. This is a case report of CPM occurring after a deceased donor LT in a patient presenting many risk factors such as chronic hyponatremia, previous episodes of encephalopathy, and tacrolimus immunosuppression. We briefly discuss the pathophysiology, risk factors, diagnosis, and treatment, highlighting the role and challenges of the anesthesiologist in managing this kind of patient and preventing the syndrome in the context of major surgery.http://www.saudija.org/article.asp?issn=1658-354X;year=2023;volume=17;issue=2;spage=275;epage=277;aulast=Biagioanesthesiacentral pontine myelinolysishyponatremialiver transplantation |
| spellingShingle | Francisco Biagio Murta e Di Flora Maurício Vitor Machado Oliveira Pedro Henrique Torres Menezes Marina Ayres Delgado Central pontine myelinolysis after liver transplant: A case report and an updated review Saudi Journal of Anaesthesia anesthesia central pontine myelinolysis hyponatremia liver transplantation |
| title | Central pontine myelinolysis after liver transplant: A case report and an updated review |
| title_full | Central pontine myelinolysis after liver transplant: A case report and an updated review |
| title_fullStr | Central pontine myelinolysis after liver transplant: A case report and an updated review |
| title_full_unstemmed | Central pontine myelinolysis after liver transplant: A case report and an updated review |
| title_short | Central pontine myelinolysis after liver transplant: A case report and an updated review |
| title_sort | central pontine myelinolysis after liver transplant a case report and an updated review |
| topic | anesthesia central pontine myelinolysis hyponatremia liver transplantation |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2023;volume=17;issue=2;spage=275;epage=277;aulast=Biagio |
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