Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature
Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissect...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2023-05-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://vestnikdv.ru/jour/article/viewFile/1386/pdf |
| _version_ | 1827906904907579392 |
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| author | Olga Yu. Olisova Natalia P. Teplyuk Olga V. Grabovskaya Diana T. Kusraeva Lyailya N. Kayumova Anna E. Bobkova Vladimir A. Varshavsky Lyudmila F. Komleva Ekaterina V. Petrenko Ksenia Yu. Bobrova |
| author_facet | Olga Yu. Olisova Natalia P. Teplyuk Olga V. Grabovskaya Diana T. Kusraeva Lyailya N. Kayumova Anna E. Bobkova Vladimir A. Varshavsky Lyudmila F. Komleva Ekaterina V. Petrenko Ksenia Yu. Bobrova |
| author_sort | Olga Yu. Olisova |
| collection | DOAJ |
| description | Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment. |
| first_indexed | 2024-03-13T01:03:11Z |
| format | Article |
| id | doaj.art-94a334b42c5741c8940d8abe84bbe109 |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-13T01:03:11Z |
| publishDate | 2023-05-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-94a334b42c5741c8940d8abe84bbe1092023-07-06T09:07:43ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942023-05-01992707910.25208/vdv13861211Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literatureOlga Yu. Olisova0https://orcid.org/0000-0003-2482-1754Natalia P. Teplyuk1https://orcid.org/0000-0002-5800-4800Olga V. Grabovskaya2https://orcid.org/0000-0002-5259-7481Diana T. Kusraeva3https://orcid.org/0000-0002-5633-7986Lyailya N. Kayumova4https://orcid.org/0000-0003-0301-737XAnna E. Bobkova5https://orcid.org/0000-0003-3611-0917Vladimir A. Varshavsky6https://orcid.org/0000-0002-5855-3092Lyudmila F. Komleva7https://orcid.org/0000-0002-7855-8480Ekaterina V. Petrenko8https://orcid.org/0000-0001-5296-5734Ksenia Yu. Bobrova9https://orcid.org/0000-0003-3645-0487I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Kaluga Region Clinical Dermatovenereologic DispensaryKaluga Region Clinical Dermatovenereologic DispensaryKaluga Region Clinical Dermatovenereologic DispensaryPyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment.https://vestnikdv.ru/jour/article/viewFile/1386/pdfpyoderma gangrenosumgranulomatosis with polyangiitiscase report |
| spellingShingle | Olga Yu. Olisova Natalia P. Teplyuk Olga V. Grabovskaya Diana T. Kusraeva Lyailya N. Kayumova Anna E. Bobkova Vladimir A. Varshavsky Lyudmila F. Komleva Ekaterina V. Petrenko Ksenia Yu. Bobrova Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature Vestnik Dermatologii i Venerologii pyoderma gangrenosum granulomatosis with polyangiitis case report |
| title | Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature |
| title_full | Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature |
| title_fullStr | Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature |
| title_full_unstemmed | Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature |
| title_short | Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature |
| title_sort | pyoderma gangrenosum mimicking granulomatosis with polyangiitis case report and riview of the literature |
| topic | pyoderma gangrenosum granulomatosis with polyangiitis case report |
| url | https://vestnikdv.ru/jour/article/viewFile/1386/pdf |
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