Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016
Abstract Background Estimates of contralateral breast cancer (CBC) risk in the modern treatment era by year of diagnosis and characteristics of the first breast cancer are needed to assess the impact of recent advances in breast cancer treatment and inform clinical decision making. Methods We examin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13058-021-01400-3 |
| _version_ | 1818434651078787072 |
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| author | Cody Ramin Diana R. Withrow Brittny C. Davis Lynn Gretchen L. Gierach Amy Berrington de González |
| author_facet | Cody Ramin Diana R. Withrow Brittny C. Davis Lynn Gretchen L. Gierach Amy Berrington de González |
| author_sort | Cody Ramin |
| collection | DOAJ |
| description | Abstract Background Estimates of contralateral breast cancer (CBC) risk in the modern treatment era by year of diagnosis and characteristics of the first breast cancer are needed to assess the impact of recent advances in breast cancer treatment and inform clinical decision making. Methods We examined CBC risk among 419,818 women (age 30–84 years) who were diagnosed with a first unilateral invasive breast cancer and survived ≥ 1 year in the US Surveillance, Epidemiology, and End Results program cancer registries from 1992 to 2015 (follow-up through 2016). CBC was defined as a second invasive breast cancer in the contralateral breast ≥ 12 months after the first breast cancer. We estimated standardized incidence ratios (SIRs) of CBC by year of diagnosis, age at diagnosis, and tumor characteristics for the first breast cancer. Cumulative incidence of CBC was calculated for women diagnosed with a first breast cancer in the recent treatment era (2004–2015, follow-up through 2016). Results Over a median follow-up of 8 years (range 1–25 years), 12,986 breast cancer patients developed CBC. Overall, breast cancer patients had approximately twice the risk of developing cancer in the contralateral breast when compared to that expected in the general population (SIR = 2.21, 95% CI = 2.17–2.25). SIRs for CBC declined by year of first diagnosis, irrespective of age at diagnosis and estrogen receptor (ER) status (p-trends < 0.001), but the strongest decline was after an ER-positive tumor. The 5-year cumulative incidence of CBC ranged from 1.01% (95% CI = 0.90–1.14%) in younger women (age < 50 years) with a first ER-positive tumor to 1.89% (95% CI = 1.61–2.21%) in younger women with a first ER-negative tumor. Conclusion Declines in CBC risk are consistent with continued advances in breast cancer treatment. The updated estimates of cumulative incidence inform breast cancer patients and clinicians on the risk of CBC and may help guide treatment decisions. |
| first_indexed | 2024-12-14T16:40:22Z |
| format | Article |
| id | doaj.art-94a4c8f0781141b180a28e54f25018c5 |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-12-14T16:40:22Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-94a4c8f0781141b180a28e54f25018c52022-12-21T22:54:21ZengBMCBreast Cancer Research1465-542X2021-02-0123111010.1186/s13058-021-01400-3Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016Cody Ramin0Diana R. Withrow1Brittny C. Davis Lynn2Gretchen L. Gierach3Amy Berrington de González4Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthIntegrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthIntegrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthAbstract Background Estimates of contralateral breast cancer (CBC) risk in the modern treatment era by year of diagnosis and characteristics of the first breast cancer are needed to assess the impact of recent advances in breast cancer treatment and inform clinical decision making. Methods We examined CBC risk among 419,818 women (age 30–84 years) who were diagnosed with a first unilateral invasive breast cancer and survived ≥ 1 year in the US Surveillance, Epidemiology, and End Results program cancer registries from 1992 to 2015 (follow-up through 2016). CBC was defined as a second invasive breast cancer in the contralateral breast ≥ 12 months after the first breast cancer. We estimated standardized incidence ratios (SIRs) of CBC by year of diagnosis, age at diagnosis, and tumor characteristics for the first breast cancer. Cumulative incidence of CBC was calculated for women diagnosed with a first breast cancer in the recent treatment era (2004–2015, follow-up through 2016). Results Over a median follow-up of 8 years (range 1–25 years), 12,986 breast cancer patients developed CBC. Overall, breast cancer patients had approximately twice the risk of developing cancer in the contralateral breast when compared to that expected in the general population (SIR = 2.21, 95% CI = 2.17–2.25). SIRs for CBC declined by year of first diagnosis, irrespective of age at diagnosis and estrogen receptor (ER) status (p-trends < 0.001), but the strongest decline was after an ER-positive tumor. The 5-year cumulative incidence of CBC ranged from 1.01% (95% CI = 0.90–1.14%) in younger women (age < 50 years) with a first ER-positive tumor to 1.89% (95% CI = 1.61–2.21%) in younger women with a first ER-negative tumor. Conclusion Declines in CBC risk are consistent with continued advances in breast cancer treatment. The updated estimates of cumulative incidence inform breast cancer patients and clinicians on the risk of CBC and may help guide treatment decisions.https://doi.org/10.1186/s13058-021-01400-3Breast cancerContralateral breast cancerSEER |
| spellingShingle | Cody Ramin Diana R. Withrow Brittny C. Davis Lynn Gretchen L. Gierach Amy Berrington de González Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 Breast Cancer Research Breast cancer Contralateral breast cancer SEER |
| title | Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 |
| title_full | Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 |
| title_fullStr | Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 |
| title_full_unstemmed | Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 |
| title_short | Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992–2016 |
| title_sort | risk of contralateral breast cancer according to first breast cancer characteristics among women in the usa 1992 2016 |
| topic | Breast cancer Contralateral breast cancer SEER |
| url | https://doi.org/10.1186/s13058-021-01400-3 |
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