Targeting Toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases

Targeting Toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases

Toll-like receptors (TLRs) are pattern recognition receptors playing a fundamental role in sensing microbial invasion and initiating innate and adaptive immune responses. TLRs are also triggered by danger signals released by injured or stressed cells during sepsis. Here we focus on studies developin...

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Bibliographic Details
Main Authors: Athina eSavva, Thierry eRoger
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Sepsis
innate immunity
therapy
Toll-like receptor
cytokine
Clinical Trial
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00387/full

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