Spheroid Culture Differentially Affects Cancer Cell Sensitivity to Drugs in Melanoma and RCC Models

Spheroid Culture Differentially Affects Cancer Cell Sensitivity to Drugs in Melanoma and RCC Models

2D culture as a model for drug testing often turns to be clinically futile. Therefore, 3D cultures (3Ds) show potential to better model responses to drugs observed in vivo. In preliminary studies, using melanoma (B16F10) and renal (RenCa) cancer, we confirmed that 3Ds better mimics the tumor microen...

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Bibliographic Details
Main Authors: Aleksandra Filipiak-Duliban, Klaudia Brodaczewska, Arkadiusz Kajdasz, Claudine Kieda
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
RCC
glutathione-s-transferases
3D
spheroids
melanoma
drug-resistance
Online Access:https://www.mdpi.com/1422-0067/23/3/1166

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