Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review
Drug-induced hypersensitivity or Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Pan African Medical Journal
2014-05-01
|
| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/18/9/pdf/9.pdf
|
| _version_ | 1823961702253723648 |
|---|---|
| author | Nissrine EL omairi Sanae Abourazzak Sanae Chaouki Samir Atmani Moustapha Hida |
| author_facet | Nissrine EL omairi Sanae Abourazzak Sanae Chaouki Samir Atmani Moustapha Hida |
| author_sort | Nissrine EL omairi |
| collection | DOAJ |
| description | Drug-induced hypersensitivity or Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Culprit drug withdrawal and corticosteroids constituted the mainstay of DRESS treatment. We describe a 6 year-old boy who presented fever and rash 4 weeks after starting carbamazepine. Investigation revealed leukocytosis, atypical lymphocytosis, and elevated serum transaminases. The diagnosis of DREES syndrome was made, Carbamazepine was stopped and replaced initially by Clobazam and by Valproic acid after discharge, no systemic corticotherapy was prescribed. Symptoms began to resolve within two weeks, and by one month later her laboratory values had returned to normal. The aim of this work is to raise awareness general practitioner and pediatricians to suspect Dress syndrome in patients who present with unusual complaints and skin findings after starting any antiepileptic drug. |
| first_indexed | 2024-12-17T17:07:43Z |
| format | Article |
| id | doaj.art-94a916e483d54d288dc3957f24bcbd48 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-17T17:07:43Z |
| publishDate | 2014-05-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-94a916e483d54d288dc3957f24bcbd482022-12-21T21:40:10ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882014-05-0118910.11604/pamj.2014.18.9.37993799Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature reviewNissrine EL omairi0Sanae Abourazzak1Sanae Chaouki2Samir Atmani3Moustapha Hida4 Pediatric Department, Hassan II University Hospital, Fes, Morocco Pediatric Department, Hassan II University Hospital, Fes, Morocco Pediatric Department, Hassan II University Hospital, Fes, Morocco Pediatric Department, Hassan II University Hospital, Fes, Morocco Pediatric Department, Hassan II University Hospital, Fes, Morocco Drug-induced hypersensitivity or Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Culprit drug withdrawal and corticosteroids constituted the mainstay of DRESS treatment. We describe a 6 year-old boy who presented fever and rash 4 weeks after starting carbamazepine. Investigation revealed leukocytosis, atypical lymphocytosis, and elevated serum transaminases. The diagnosis of DREES syndrome was made, Carbamazepine was stopped and replaced initially by Clobazam and by Valproic acid after discharge, no systemic corticotherapy was prescribed. Symptoms began to resolve within two weeks, and by one month later her laboratory values had returned to normal. The aim of this work is to raise awareness general practitioner and pediatricians to suspect Dress syndrome in patients who present with unusual complaints and skin findings after starting any antiepileptic drug. https://www.panafrican-med-journal.com/content/article/18/9/pdf/9.pdf epilepsycarbamazepinerashdress syndrome |
| spellingShingle | Nissrine EL omairi Sanae Abourazzak Sanae Chaouki Samir Atmani Moustapha Hida Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review The Pan African Medical Journal epilepsy carbamazepine rash dress syndrome |
| title | Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review |
| title_full | Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review |
| title_fullStr | Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review |
| title_full_unstemmed | Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review |
| title_short | Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review |
| title_sort | drug reaction with eosinophilia and systemic symptom dress induced by carbamazepine a case report and literature review |
| topic | epilepsy carbamazepine rash dress syndrome |
| url |
https://www.panafrican-med-journal.com/content/article/18/9/pdf/9.pdf
|
| work_keys_str_mv | AT nissrineelomairi drugreactionwitheosinophiliaandsystemicsymptomdressinducedbycarbamazepineacasereportandliteraturereview AT sanaeabourazzak drugreactionwitheosinophiliaandsystemicsymptomdressinducedbycarbamazepineacasereportandliteraturereview AT sanaechaouki drugreactionwitheosinophiliaandsystemicsymptomdressinducedbycarbamazepineacasereportandliteraturereview AT samiratmani drugreactionwitheosinophiliaandsystemicsymptomdressinducedbycarbamazepineacasereportandliteraturereview AT moustaphahida drugreactionwitheosinophiliaandsystemicsymptomdressinducedbycarbamazepineacasereportandliteraturereview |