Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study
Aim. To assess the potential of using oral fluid as a non-invasive diagnostic material in patients with myocardial infarction (MI).Material and methods. The pilot, single-center, prospective study included 47 patients with documented MI, among whom there were 33 men (71%) and 14 women (29%) (mean ag...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2020-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3814 |
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| author | A. M. Chaulin P. D. Duplyakova G. R. Bikbaeva A. A. Tukhbatova E. V. Grigorieva D. V. Duplyakov |
| author_facet | A. M. Chaulin P. D. Duplyakova G. R. Bikbaeva A. A. Tukhbatova E. V. Grigorieva D. V. Duplyakov |
| author_sort | A. M. Chaulin |
| collection | DOAJ |
| description | Aim. To assess the potential of using oral fluid as a non-invasive diagnostic material in patients with myocardial infarction (MI).Material and methods. The pilot, single-center, prospective study included 47 patients with documented MI, among whom there were 33 men (71%) and 14 women (29%) (mean age, 61,72±12,09 years). All patients successfully treated with reperfusion therapy. The control group consisted of 15 people in whom MI was not confirmed. The concentration of high-sensitivity cardiac tro -ponin I ( hs-cTnI) in blood and oral fluid was determined using chemilumines -cence enzyme immunoassay (CLEIA) on a PATHFAST analyzer (LSI Medience Corporation). Medium sensitivity cardiac troponin I (ms-cTnI) was determined in blood using an Access 2 immunoassay system analyzer (Beckman Coulter, USA). Levels of total bilirubin, creatinine, glucose, rheumatoid factor, alkaline phosphatase and other biochemical parameters were determined on a Furuno CA-400 analyzer (Japan).Results. The levels of hs-cTnI in patients with MI were significantly higher than in healthy patients both in blood (8,73±1,17 ng/ml vs 0,012±0,03 ng/ml, p<0,001) and oral fluid (0,41±0,11 ng/ml vs 0,004±0,001 ng/ml, p<0,001). In patients with-AMI, there was a moderate correlation between the concentration of hs-cTnI in the serum and the oral fluid (r=0,319; p<0,05).The serum level of hs-cTnI in patients with Q-wave (n=33) and non-Q-wave (n=14) MI was 10,11±1,53 ng/ ml vs 5,48±1,29 ng/ml, respectively (p=0,025). The oral fluid concentration of hs-cTnI in patients with W-wave (n=33) and non-Q-wave (n=14) MI was 0,42±0,14 ng/ml vs 0,40±0,16 ng/ml, respectively (p=0,925).The serum level of hs-cTnI in anterior MI (n=19) was 8,92±2,06 ng/ml vs 8,91±1,81 ng/ml in posterior one (n=23) (p=0,997). The concentration of hs-cTnI in the oral fluid was 0,21±0,06 ng/ml vs 0,57±0,21 ng/ml, respectively (p=0,107).The oral fluid concentrations of hs-TnI in patients with MI using conventional plastic tubes (n=26) and special Sarstedt microtubes (n=21) were 0,56±0,19 ng/ml and 0,22±0,10 ng/ml, respectively (p=0,12).Conclusion. This pilot study has proven the possibility of detecting hs-cTnI in the oral fluid of patients with MI. There was a moderate correlation between the level of hs-cTnI in blood serum and oral fluid. Further research is needed to determine the hs-cTnI reference values in the oral fluid of patients with MI. |
| first_indexed | 2024-04-09T20:44:44Z |
| format | Article |
| id | doaj.art-94ad0c4aba5343c2b7fb32390786bcdd |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:44:44Z |
| publishDate | 2020-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-94ad0c4aba5343c2b7fb32390786bcdd2023-03-29T21:23:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-12-01251210.15829/1560-4071-2020-38142895Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot studyA. M. Chaulin0P. D. Duplyakova1G. R. Bikbaeva2A. A. Tukhbatova3E. V. Grigorieva4D. V. Duplyakov5Samara Regional Clinical Cardiology Dispensary; Samara State Medical UniversitySamara State Medical UniversitySamara Regional Clinical Cardiology DispensarySamara Regional Clinical Cardiology DispensarySamara Regional Clinical Cardiology DispensarySamara State Medical University, Samara regional Cardiology DispensaryAim. To assess the potential of using oral fluid as a non-invasive diagnostic material in patients with myocardial infarction (MI).Material and methods. The pilot, single-center, prospective study included 47 patients with documented MI, among whom there were 33 men (71%) and 14 women (29%) (mean age, 61,72±12,09 years). All patients successfully treated with reperfusion therapy. The control group consisted of 15 people in whom MI was not confirmed. The concentration of high-sensitivity cardiac tro -ponin I ( hs-cTnI) in blood and oral fluid was determined using chemilumines -cence enzyme immunoassay (CLEIA) on a PATHFAST analyzer (LSI Medience Corporation). Medium sensitivity cardiac troponin I (ms-cTnI) was determined in blood using an Access 2 immunoassay system analyzer (Beckman Coulter, USA). Levels of total bilirubin, creatinine, glucose, rheumatoid factor, alkaline phosphatase and other biochemical parameters were determined on a Furuno CA-400 analyzer (Japan).Results. The levels of hs-cTnI in patients with MI were significantly higher than in healthy patients both in blood (8,73±1,17 ng/ml vs 0,012±0,03 ng/ml, p<0,001) and oral fluid (0,41±0,11 ng/ml vs 0,004±0,001 ng/ml, p<0,001). In patients with-AMI, there was a moderate correlation between the concentration of hs-cTnI in the serum and the oral fluid (r=0,319; p<0,05).The serum level of hs-cTnI in patients with Q-wave (n=33) and non-Q-wave (n=14) MI was 10,11±1,53 ng/ ml vs 5,48±1,29 ng/ml, respectively (p=0,025). The oral fluid concentration of hs-cTnI in patients with W-wave (n=33) and non-Q-wave (n=14) MI was 0,42±0,14 ng/ml vs 0,40±0,16 ng/ml, respectively (p=0,925).The serum level of hs-cTnI in anterior MI (n=19) was 8,92±2,06 ng/ml vs 8,91±1,81 ng/ml in posterior one (n=23) (p=0,997). The concentration of hs-cTnI in the oral fluid was 0,21±0,06 ng/ml vs 0,57±0,21 ng/ml, respectively (p=0,107).The oral fluid concentrations of hs-TnI in patients with MI using conventional plastic tubes (n=26) and special Sarstedt microtubes (n=21) were 0,56±0,19 ng/ml and 0,22±0,10 ng/ml, respectively (p=0,12).Conclusion. This pilot study has proven the possibility of detecting hs-cTnI in the oral fluid of patients with MI. There was a moderate correlation between the level of hs-cTnI in blood serum and oral fluid. Further research is needed to determine the hs-cTnI reference values in the oral fluid of patients with MI.https://russjcardiol.elpub.ru/jour/article/view/3814high-sensitivity cardiac troponin imyocardial infarctionnon-invasive diagnosticsoral fluid |
| spellingShingle | A. M. Chaulin P. D. Duplyakova G. R. Bikbaeva A. A. Tukhbatova E. V. Grigorieva D. V. Duplyakov Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study Российский кардиологический журнал high-sensitivity cardiac troponin i myocardial infarction non-invasive diagnostics oral fluid |
| title | Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study |
| title_full | Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study |
| title_fullStr | Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study |
| title_full_unstemmed | Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study |
| title_short | Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study |
| title_sort | concentration of high sensitivity cardiac troponin i in the oral fluid in patients with acute myocardial infarction a pilot study |
| topic | high-sensitivity cardiac troponin i myocardial infarction non-invasive diagnostics oral fluid |
| url | https://russjcardiol.elpub.ru/jour/article/view/3814 |
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