Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells
Summary: A number of new cell death processes have been discovered in recent years, including ferroptosis, which is characterized by the accumulation of lipid peroxidation products derived from iron metabolism. The evidence suggests that ferroptosis has a tumor-suppressor function. However, the mech...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221008051 |
| _version_ | 1818645075168591872 |
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| author | Xianjin Kan Yuncong Yin Cuiping Song Lei Tan Xusheng Qiu Ying Liao Weiwei Liu Songshu Meng Yingjie Sun Chan Ding |
| author_facet | Xianjin Kan Yuncong Yin Cuiping Song Lei Tan Xusheng Qiu Ying Liao Weiwei Liu Songshu Meng Yingjie Sun Chan Ding |
| author_sort | Xianjin Kan |
| collection | DOAJ |
| description | Summary: A number of new cell death processes have been discovered in recent years, including ferroptosis, which is characterized by the accumulation of lipid peroxidation products derived from iron metabolism. The evidence suggests that ferroptosis has a tumor-suppressor function. However, the mechanism by which ferroptosis mediates the response of tumor cells to oncolytic viruses remains poorly understood. The Newcastle disease virus (NDV) can selectively replicate in tumor cells. We show that NDV-induced ferroptosis acts through p53-SLC7A11-GPX4 pathway. Meanwhile, the levels of intracellular reactive oxygen species and lipid peroxides increased in tumor cells. Ferritinophagy was induced by NDV promotion of ferroptosis through the release of ferrous iron and an enhanced Fenton reaction. Collectively, these observations demonstrated that the NDV can kill tumor cells through ferroptosis. Our study provides novel insights into the mechanisms of NDV-induced ferroptosis and highlights the critical role of viruses in treating therapy-resistant cancers. |
| first_indexed | 2024-12-17T00:24:58Z |
| format | Article |
| id | doaj.art-94ad7a8b359d48d98daff18aebd4b470 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T00:24:58Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-94ad7a8b359d48d98daff18aebd4b4702022-12-21T22:10:29ZengElsevieriScience2589-00422021-08-01248102837Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cellsXianjin Kan0Yuncong Yin1Cuiping Song2Lei Tan3Xusheng Qiu4Ying Liao5Weiwei Liu6Songshu Meng7Yingjie Sun8Chan Ding9Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. ChinaInstitute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, PR ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. China; Corresponding authorDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai 200241, P.R. China; College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; Corresponding authorSummary: A number of new cell death processes have been discovered in recent years, including ferroptosis, which is characterized by the accumulation of lipid peroxidation products derived from iron metabolism. The evidence suggests that ferroptosis has a tumor-suppressor function. However, the mechanism by which ferroptosis mediates the response of tumor cells to oncolytic viruses remains poorly understood. The Newcastle disease virus (NDV) can selectively replicate in tumor cells. We show that NDV-induced ferroptosis acts through p53-SLC7A11-GPX4 pathway. Meanwhile, the levels of intracellular reactive oxygen species and lipid peroxides increased in tumor cells. Ferritinophagy was induced by NDV promotion of ferroptosis through the release of ferrous iron and an enhanced Fenton reaction. Collectively, these observations demonstrated that the NDV can kill tumor cells through ferroptosis. Our study provides novel insights into the mechanisms of NDV-induced ferroptosis and highlights the critical role of viruses in treating therapy-resistant cancers.http://www.sciencedirect.com/science/article/pii/S2589004221008051Biological sciencesVirologyCell biologyCancer |
| spellingShingle | Xianjin Kan Yuncong Yin Cuiping Song Lei Tan Xusheng Qiu Ying Liao Weiwei Liu Songshu Meng Yingjie Sun Chan Ding Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells iScience Biological sciences Virology Cell biology Cancer |
| title | Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| title_full | Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| title_fullStr | Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| title_full_unstemmed | Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| title_short | Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| title_sort | newcastle disease virus induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells |
| topic | Biological sciences Virology Cell biology Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221008051 |
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