Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns
Objectives: To evaluate the association between oxidative and inflammatory stress markers with peri‐intraventricular hemorrhage (PIVH) in very‐low birth weight newborns. Methods: This was a prospective study conducted in a level III neonatal unit. Basal and stimulated reactive oxygen intermediates (...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2015-07-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S225555361500066X |
| _version_ | 1811255181908639744 |
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| author | Jamil P.S. Caldas Carolina A. Braghini Taís N. Mazzola Maria M.S. Vilela Sérgio T.M. Marba |
| author_facet | Jamil P.S. Caldas Carolina A. Braghini Taís N. Mazzola Maria M.S. Vilela Sérgio T.M. Marba |
| author_sort | Jamil P.S. Caldas |
| collection | DOAJ |
| description | Objectives: To evaluate the association between oxidative and inflammatory stress markers with peri‐intraventricular hemorrhage (PIVH) in very‐low birth weight newborns.
Methods: This was a prospective study conducted in a level III neonatal unit. Basal and stimulated reactive oxygen intermediates (ROIs), reduced glutathione (GSH), and interleukin‐6 (IL‐6) levels were measured in umbilical cord blood. Newborns underwent serial ultrasound at the bedside, at 6, 12, 24, and 72 hours of life and at seven days for the diagnosis of PIVH, classified as grades I to IV. Two groups were assessed, those with and without PIVH; maternal and neonatal control variables were used for comparison. Univariate and multiple regression analyses were applied.
Results: A total of 125 newborns were assessed. PIVH incidence rate was 12.0%. In the univariate analysis, basal ROI, the use of two or more doses of corticosteroids, birth weight < 1,000 g, ventilatory support use, and SNAPPE II value ≥ 22 were significantly associated with PIVH. However, in the multivariate analysis, only antenatal steroid use was independently associated with the disease (OR 1.94; 95% CI: 0.048 to 0.773; p = 0.02).
Conclusion: ROI, GSH, and IL‐6 levels were not associated with the occurrence of PIVH in very‐low birth weight infants. |
| first_indexed | 2024-04-12T17:19:54Z |
| format | Article |
| id | doaj.art-94adfff62664489cb43f2c5465fc7eeb |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T17:19:54Z |
| publishDate | 2015-07-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-94adfff62664489cb43f2c5465fc7eeb2022-12-22T03:23:31ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362015-07-0191437337910.1016/j.jpedp.2015.05.003Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newbornsJamil P.S. Caldas0Carolina A. Braghini1Taís N. Mazzola2Maria M.S. Vilela3Sérgio T.M. Marba4Divisão de Neonatologia, Hospital da Mulher Prof. Dr. José Aristodemo Pinotti, Centro de Atenção Integral à Saúde da Mulher (CAISM), Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrasilCentro de Investigação em Pediatria (Ciped), Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrasilCentro de Investigação em Pediatria (Ciped), Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrasilDepartamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrasilDepartamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrasilObjectives: To evaluate the association between oxidative and inflammatory stress markers with peri‐intraventricular hemorrhage (PIVH) in very‐low birth weight newborns. Methods: This was a prospective study conducted in a level III neonatal unit. Basal and stimulated reactive oxygen intermediates (ROIs), reduced glutathione (GSH), and interleukin‐6 (IL‐6) levels were measured in umbilical cord blood. Newborns underwent serial ultrasound at the bedside, at 6, 12, 24, and 72 hours of life and at seven days for the diagnosis of PIVH, classified as grades I to IV. Two groups were assessed, those with and without PIVH; maternal and neonatal control variables were used for comparison. Univariate and multiple regression analyses were applied. Results: A total of 125 newborns were assessed. PIVH incidence rate was 12.0%. In the univariate analysis, basal ROI, the use of two or more doses of corticosteroids, birth weight < 1,000 g, ventilatory support use, and SNAPPE II value ≥ 22 were significantly associated with PIVH. However, in the multivariate analysis, only antenatal steroid use was independently associated with the disease (OR 1.94; 95% CI: 0.048 to 0.773; p = 0.02). Conclusion: ROI, GSH, and IL‐6 levels were not associated with the occurrence of PIVH in very‐low birth weight infants.http://www.sciencedirect.com/science/article/pii/S225555361500066XOxidative stressReactive oxygen speciesInterleukin‐6GlutathioneIntraventricular hemorrhageNewborn |
| spellingShingle | Jamil P.S. Caldas Carolina A. Braghini Taís N. Mazzola Maria M.S. Vilela Sérgio T.M. Marba Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns Jornal de Pediatria (Versão em Português) Oxidative stress Reactive oxygen species Interleukin‐6 Glutathione Intraventricular hemorrhage Newborn |
| title | Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns |
| title_full | Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns |
| title_fullStr | Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns |
| title_full_unstemmed | Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns |
| title_short | Peri‐intraventricular hemorrhage and oxidative and inflammatory stress markers in very‐low birth weight newborns |
| title_sort | peri intraventricular hemorrhage and oxidative and inflammatory stress markers in very low birth weight newborns |
| topic | Oxidative stress Reactive oxygen species Interleukin‐6 Glutathione Intraventricular hemorrhage Newborn |
| url | http://www.sciencedirect.com/science/article/pii/S225555361500066X |
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