Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
<p>Abstract</p> <p>Background</p> <p>Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-07-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://www.ijponline.net/content/37/1/34 |
| _version_ | 1819038392528142336 |
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| author | Osman Mohammed Sanad Mohammed Gharib Amal |
| author_facet | Osman Mohammed Sanad Mohammed Gharib Amal |
| author_sort | Osman Mohammed |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children.</p> <p>Methods</p> <p>This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA.</p> <p>Results</p> <p>Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05).</p> <p>Conclusions</p> <p>Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia.</p> |
| first_indexed | 2024-12-21T08:36:35Z |
| format | Article |
| id | doaj.art-94b27f1761f54e51bc2cc399da7ee210 |
| institution | Directory Open Access Journal |
| issn | 1720-8424 1824-7288 |
| language | English |
| last_indexed | 2024-12-21T08:36:35Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-94b27f1761f54e51bc2cc399da7ee2102022-12-21T19:10:03ZengBMCItalian Journal of Pediatrics1720-84241824-72882011-07-013713410.1186/1824-7288-37-34Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control studyOsman MohammedSanad MohammedGharib Amal<p>Abstract</p> <p>Background</p> <p>Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children.</p> <p>Methods</p> <p>This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA.</p> <p>Results</p> <p>Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05).</p> <p>Conclusions</p> <p>Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia.</p>http://www.ijponline.net/content/37/1/34ObesityHepcidinIron deficiencyChildren |
| spellingShingle | Osman Mohammed Sanad Mohammed Gharib Amal Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study Italian Journal of Pediatrics Obesity Hepcidin Iron deficiency Children |
| title | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
| title_full | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
| title_fullStr | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
| title_full_unstemmed | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
| title_short | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
| title_sort | obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children a case control study |
| topic | Obesity Hepcidin Iron deficiency Children |
| url | http://www.ijponline.net/content/37/1/34 |
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