Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems

Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems

Early life challenges resulting from maternal immune activation (MIA) may exert persistent effects on the offspring, including the development of psychiatric disorders, such as schizophrenia. Recent evidence has suggested that the adverse effects of MIA may be mediated by neuron–microglia crosstalk,...

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Bibliographic Details
Main Authors: Katarzyna Chamera, Magdalena Szuster-Głuszczak, Ewa Trojan, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
prenatal immune challenge
lipopolysaccharide
CX3CL1–CX3CR1
CD200–CD200R
microglia
two-hit
Online Access:https://www.mdpi.com/2073-4409/9/7/1676

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