Determination of Binding Affinity of Antibodies to HIV-1 Recombinant Envelope Glycoproteins, Pseudoviruses, Infectious Molecular Clones, and Cell-Expressed Trimeric gp160 Using Microscale Thermophoresis

Determination of Binding Affinity of Antibodies to HIV-1 Recombinant Envelope Glycoproteins, Pseudoviruses, Infectious Molecular Clones, and Cell-Expressed Trimeric gp160 Using Microscale Thermophoresis

Developing a preventative vaccine for HIV-1 has been a global priority. The elicitation of broadly neutralizing antibodies (bNAbs) against a broad range of HIV-1 envelopes (Envs) from various strains appears to be a critical requirement for an efficacious HIV-1 vaccine. To understand their ability t...

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Bibliographic Details
Main Authors: Shraddha Basu, Neelakshi Gohain, Jiae Kim, Hung V. Trinh, Misook Choe, M. Gordon Joyce, Mangala Rao
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
HIV-1 epitopes
MST
binding affinity
recombinant HIV-1 proteins
pseudovirus
infectious molecular clone
Online Access:https://www.mdpi.com/2073-4409/13/1/33

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