Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste
The yield of essential oils in plants is not high and postdistillation wastes rich in phenolic compounds could be used to enhance the profitability of essential oil-bearing plants. The aim of the study was to evaluate polyphenols in a dry extract obtained from the postdistillation waste of the Ameri...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/12/3063 |
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| author | Izabela Jasicka-Misiak Mariia Shanaida Nataliia Hudz Piotr Paweł Wieczorek |
| author_facet | Izabela Jasicka-Misiak Mariia Shanaida Nataliia Hudz Piotr Paweł Wieczorek |
| author_sort | Izabela Jasicka-Misiak |
| collection | DOAJ |
| description | The yield of essential oils in plants is not high and postdistillation wastes rich in phenolic compounds could be used to enhance the profitability of essential oil-bearing plants. The aim of the study was to evaluate polyphenols in a dry extract obtained from the postdistillation waste of the American basil (<i>Ocimum americanum</i> L.) herb, and to conduct the screening of its pharmacological activities. Rosmarinic acid, caffeic acid and rutin were identified in the extract using high-performance thin-layer chromatography. The high-performance liquid chromatography analysis found the presence of a plethora of polyphenols in the extract. Rosmarinic acid, luteolin-7-<i>O</i>-glucoside and rutin were as the main compounds. The total phenolic content in the extract was 106.31 mg GAE/g and free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl evaluated as IC<sub>50</sub> was 0.298 mg/mL. The tested extract dose-dependently decreased the paw edema in rats, suggesting its potent anti-inflammatory property. The acute toxicity study indicates its safety. Thus, the <i>O. americanum</i> hydrodistilled residue by-product is the promising source of biologically active compounds with significant antioxidant and anti-inflammatory effects. |
| first_indexed | 2024-03-10T04:08:22Z |
| format | Article |
| id | doaj.art-94b6db6166d54b5fb3f3c9ff5bedfec2 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T04:08:22Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-94b6db6166d54b5fb3f3c9ff5bedfec22023-11-23T08:18:19ZengMDPI AGFoods2304-81582021-12-011012306310.3390/foods10123063Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation WasteIzabela Jasicka-Misiak0Mariia Shanaida1Nataliia Hudz2Piotr Paweł Wieczorek3Department of Pharmacy and Ecological Chemistry, University of Opole, 45-052 Opole, PolandDepartment of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, 46-001 Ternopil, UkraineDepartment of Pharmacy and Ecological Chemistry, University of Opole, 45-052 Opole, PolandDepartment of Analytical Chemistry, University of Opole, 45-052 Opole, PolandThe yield of essential oils in plants is not high and postdistillation wastes rich in phenolic compounds could be used to enhance the profitability of essential oil-bearing plants. The aim of the study was to evaluate polyphenols in a dry extract obtained from the postdistillation waste of the American basil (<i>Ocimum americanum</i> L.) herb, and to conduct the screening of its pharmacological activities. Rosmarinic acid, caffeic acid and rutin were identified in the extract using high-performance thin-layer chromatography. The high-performance liquid chromatography analysis found the presence of a plethora of polyphenols in the extract. Rosmarinic acid, luteolin-7-<i>O</i>-glucoside and rutin were as the main compounds. The total phenolic content in the extract was 106.31 mg GAE/g and free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl evaluated as IC<sub>50</sub> was 0.298 mg/mL. The tested extract dose-dependently decreased the paw edema in rats, suggesting its potent anti-inflammatory property. The acute toxicity study indicates its safety. Thus, the <i>O. americanum</i> hydrodistilled residue by-product is the promising source of biologically active compounds with significant antioxidant and anti-inflammatory effects.https://www.mdpi.com/2304-8158/10/12/3063American basilherbhydrodistilled residue by-productsafetypolyphenolsantioxidant activity |
| spellingShingle | Izabela Jasicka-Misiak Mariia Shanaida Nataliia Hudz Piotr Paweł Wieczorek Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste Foods American basil herb hydrodistilled residue by-product safety polyphenols antioxidant activity |
| title | Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste |
| title_full | Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste |
| title_fullStr | Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste |
| title_full_unstemmed | Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste |
| title_short | Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the <i>Ocimum americanum</i> (<i>Lamiaceae</i>) Postdistillation Waste |
| title_sort | phytochemical and pharmacological evaluation of the residue by product developed from the i ocimum americanum i i lamiaceae i postdistillation waste |
| topic | American basil herb hydrodistilled residue by-product safety polyphenols antioxidant activity |
| url | https://www.mdpi.com/2304-8158/10/12/3063 |
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