The role of p53 in liver fibrosis
The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and development of liver fibrosis. The abundant post-translational processing and modification endow the functional diversity of p53. Co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1057829/full |
| _version_ | 1798030740211892224 |
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| author | Siyu Yu Guang Ji Li Zhang |
| author_facet | Siyu Yu Guang Ji Li Zhang |
| author_sort | Siyu Yu |
| collection | DOAJ |
| description | The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and development of liver fibrosis. The abundant post-translational processing and modification endow the functional diversity of p53. Considering the relationship between p53 and liver fibrosis, drug intervention targeting p53 or management of p53 regulation might be effective strategies to treat liver fibrosis. Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, etc) and the role of p53 in the development of liver fibrosis, and propose possible interventions to prevent the pathogenic processes of liver fibrosis. |
| first_indexed | 2024-04-11T19:45:06Z |
| format | Article |
| id | doaj.art-94b76eb48d3b4cf8914e6c08530ff5a6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T19:45:06Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-94b76eb48d3b4cf8914e6c08530ff5a62022-12-22T04:06:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10578291057829The role of p53 in liver fibrosisSiyu YuGuang JiLi ZhangThe tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and development of liver fibrosis. The abundant post-translational processing and modification endow the functional diversity of p53. Considering the relationship between p53 and liver fibrosis, drug intervention targeting p53 or management of p53 regulation might be effective strategies to treat liver fibrosis. Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, etc) and the role of p53 in the development of liver fibrosis, and propose possible interventions to prevent the pathogenic processes of liver fibrosis.https://www.frontiersin.org/articles/10.3389/fphar.2022.1057829/fullliver fibrosisp53hepatic stellate cellsapoptosisferroptosis |
| spellingShingle | Siyu Yu Guang Ji Li Zhang The role of p53 in liver fibrosis Frontiers in Pharmacology liver fibrosis p53 hepatic stellate cells apoptosis ferroptosis |
| title | The role of p53 in liver fibrosis |
| title_full | The role of p53 in liver fibrosis |
| title_fullStr | The role of p53 in liver fibrosis |
| title_full_unstemmed | The role of p53 in liver fibrosis |
| title_short | The role of p53 in liver fibrosis |
| title_sort | role of p53 in liver fibrosis |
| topic | liver fibrosis p53 hepatic stellate cells apoptosis ferroptosis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1057829/full |
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