Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach
ABSTRACT Altered metabolites level in the biosystems, is the potential cause of cancer, the primary reason of alteration of metabolism is change in nutrient consumption and waste excretion, as a result genetic mutation leads to cancer initiation and progression. Aberration of specific metabolites su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2018-07-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200603&lng=en&tlng=en |
| _version_ | 1818756771450191872 |
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| author | Debmalya Roy Cheng Chen Jun-song Wang Shengtao Yuan Li Sun |
| author_facet | Debmalya Roy Cheng Chen Jun-song Wang Shengtao Yuan Li Sun |
| author_sort | Debmalya Roy |
| collection | DOAJ |
| description | ABSTRACT Altered metabolites level in the biosystems, is the potential cause of cancer, the primary reason of alteration of metabolism is change in nutrient consumption and waste excretion, as a result genetic mutation leads to cancer initiation and progression. Aberration of specific metabolites such as fumarate, succinate, 2-hydroxyglutarate may alter cell signaling. We collected liver and kidney samples and prepared for 1H NMR analysis, then executed NMR spectroscopy. We used a set of domestic R scripts to perform an unsupervised principal component analysis (PCA) and a supervised orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA). It signifies class discrimination for getting a clear separation, whereas PCA scores plot signifies the model group kept further away from the control group than drug group on the horizontal axis. In another PCA scores plots, most parts of the control group was overlapping with the drug group but was distant from the model group. Marsdenia tenacissima extract (MTE) (Chines name: Xiao-Ai-Ping, XAP) modulates level of crucial metabolites such as fumarate, lactate, succinate, determined by 1H NMR spectroscopy and their altered level contributes major role in cancer. |
| first_indexed | 2024-12-18T06:00:20Z |
| format | Article |
| id | doaj.art-94b8d80dfcab4d7580f499d668832262 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-18T06:00:20Z |
| publishDate | 2018-07-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-94b8d80dfcab4d7580f499d6688322622022-12-21T21:18:41ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902018-07-0154210.1590/s2175-97902018000217604S1984-82502018000200603Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approachDebmalya RoyCheng ChenJun-song WangShengtao YuanLi SunABSTRACT Altered metabolites level in the biosystems, is the potential cause of cancer, the primary reason of alteration of metabolism is change in nutrient consumption and waste excretion, as a result genetic mutation leads to cancer initiation and progression. Aberration of specific metabolites such as fumarate, succinate, 2-hydroxyglutarate may alter cell signaling. We collected liver and kidney samples and prepared for 1H NMR analysis, then executed NMR spectroscopy. We used a set of domestic R scripts to perform an unsupervised principal component analysis (PCA) and a supervised orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA). It signifies class discrimination for getting a clear separation, whereas PCA scores plot signifies the model group kept further away from the control group than drug group on the horizontal axis. In another PCA scores plots, most parts of the control group was overlapping with the drug group but was distant from the model group. Marsdenia tenacissima extract (MTE) (Chines name: Xiao-Ai-Ping, XAP) modulates level of crucial metabolites such as fumarate, lactate, succinate, determined by 1H NMR spectroscopy and their altered level contributes major role in cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200603&lng=en&tlng=enMarsdenia tenacissima extract (MTE)MDA-MB-2311H NMRMetabolomics |
| spellingShingle | Debmalya Roy Cheng Chen Jun-song Wang Shengtao Yuan Li Sun Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach Brazilian Journal of Pharmaceutical Sciences Marsdenia tenacissima extract (MTE) MDA-MB-231 1H NMR Metabolomics |
| title | Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach |
| title_full | Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach |
| title_fullStr | Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach |
| title_full_unstemmed | Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach |
| title_short | Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach |
| title_sort | marsdenia tenacissima extract alters crucial metabolites in cancer determined by 1 h nmr based metabolomics approach |
| topic | Marsdenia tenacissima extract (MTE) MDA-MB-231 1H NMR Metabolomics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200603&lng=en&tlng=en |
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