Cellular and genetic drivers of RNA editing variation in the human brain
Here the authors provide a deep catalogue of cell-specific A-to-I editing sites in the human cortex. Thousands of sites are enriched and elevated in neurons relative to glial cells, and are genetically regulated across multiple brain regions.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30531-0 |
| _version_ | 1828732736999784448 |
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| author | Winston H. Cuddleston Junhao Li Xuanjia Fan Alexey Kozenkov Matthew Lalli Shahrukh Khalique Stella Dracheva Eran A. Mukamel Michael S. Breen |
| author_facet | Winston H. Cuddleston Junhao Li Xuanjia Fan Alexey Kozenkov Matthew Lalli Shahrukh Khalique Stella Dracheva Eran A. Mukamel Michael S. Breen |
| author_sort | Winston H. Cuddleston |
| collection | DOAJ |
| description | Here the authors provide a deep catalogue of cell-specific A-to-I editing sites in the human cortex. Thousands of sites are enriched and elevated in neurons relative to glial cells, and are genetically regulated across multiple brain regions. |
| first_indexed | 2024-04-12T18:06:25Z |
| format | Article |
| id | doaj.art-94b9835f6e944fd1a0451ac9750274c3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T18:06:25Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-94b9835f6e944fd1a0451ac9750274c32022-12-22T03:21:58ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30531-0Cellular and genetic drivers of RNA editing variation in the human brainWinston H. Cuddleston0Junhao Li1Xuanjia Fan2Alexey Kozenkov3Matthew Lalli4Shahrukh Khalique5Stella Dracheva6Eran A. Mukamel7Michael S. Breen8Department of Psychiatry at Mount SinaiDepartment of Cognitive Science, University of California, San DiegoDepartment of Psychiatry at Mount SinaiDepartment of Psychiatry at Mount SinaiDepartment of Psychiatry at Mount SinaiDepartment of Psychiatry at Mount SinaiDepartment of Psychiatry at Mount SinaiDepartment of Cognitive Science, University of California, San DiegoDepartment of Psychiatry at Mount SinaiHere the authors provide a deep catalogue of cell-specific A-to-I editing sites in the human cortex. Thousands of sites are enriched and elevated in neurons relative to glial cells, and are genetically regulated across multiple brain regions.https://doi.org/10.1038/s41467-022-30531-0 |
| spellingShingle | Winston H. Cuddleston Junhao Li Xuanjia Fan Alexey Kozenkov Matthew Lalli Shahrukh Khalique Stella Dracheva Eran A. Mukamel Michael S. Breen Cellular and genetic drivers of RNA editing variation in the human brain Nature Communications |
| title | Cellular and genetic drivers of RNA editing variation in the human brain |
| title_full | Cellular and genetic drivers of RNA editing variation in the human brain |
| title_fullStr | Cellular and genetic drivers of RNA editing variation in the human brain |
| title_full_unstemmed | Cellular and genetic drivers of RNA editing variation in the human brain |
| title_short | Cellular and genetic drivers of RNA editing variation in the human brain |
| title_sort | cellular and genetic drivers of rna editing variation in the human brain |
| url | https://doi.org/10.1038/s41467-022-30531-0 |
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