Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma
The brain tumors and especially glioblastoma, are affecting life of many people worldwide and due to their high mortality and morbidity, their treatment is of importance and has gained attention in recent years. The abnormal expression of genes is commonly observed in GBM and long non-coding RNAs (l...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-06-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000234 |
| _version_ | 1797234053227741184 |
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| author | Mehrdad Hashemi Sophie Mousavian Roshanzamir Sima Orouei Pouria Daneii Rasoul Raesi Haleh Zokaee Pooria Bikarannejad Kiana Salmani Ramin Khorrami Mahshid Deldar Abad Paskeh Shokooh Salimimoghadam Mohsen Rashidi Kiavash Hushmandi Afshin Taheriazam Maliheh Entezari |
| author_facet | Mehrdad Hashemi Sophie Mousavian Roshanzamir Sima Orouei Pouria Daneii Rasoul Raesi Haleh Zokaee Pooria Bikarannejad Kiana Salmani Ramin Khorrami Mahshid Deldar Abad Paskeh Shokooh Salimimoghadam Mohsen Rashidi Kiavash Hushmandi Afshin Taheriazam Maliheh Entezari |
| author_sort | Mehrdad Hashemi |
| collection | DOAJ |
| description | The brain tumors and especially glioblastoma, are affecting life of many people worldwide and due to their high mortality and morbidity, their treatment is of importance and has gained attention in recent years. The abnormal expression of genes is commonly observed in GBM and long non-coding RNAs (lncRNAs) have demonstrated dysregulation in this tumor. LncRNAs have length more than 200 nucleotides and they have been located in cytoplasm and nucleus. The current review focuses on the role of lncRNAs in GBM. There two types of lncRNAs in GBM including tumor-promoting and tumor-suppressor lncRNAs and overexpression of oncogenic lncRNAs increases progression of GBM. LncRNAs can regulate proliferation, cell cycle arrest and metastasis of GBM cells. Wnt, STAT3 and EZH2 are among the molecular pathways affected by lncRNAs in GBM and for regulating metastasis of GBM cells, these RNA molecules mainly affect EMT mechanism. LncRNAs are involved in drug resistance and can induce resistance of GBM cells to temozolomide chemotherapy. Furthermore, lncRNAs stimulate radio-resistance in GBM cells. LncRNAs increase PD-1 expression to mediate immune evasion. LncRNAs can be considered as diagnostic and prognostic tools in GBM and researchers have developed signature from lncRNAs in GBM. |
| first_indexed | 2024-04-24T16:25:57Z |
| format | Article |
| id | doaj.art-94bc390496b044a6bbd9ae4bd4fd986f |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T16:25:57Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-94bc390496b044a6bbd9ae4bd4fd986f2024-03-31T04:37:49ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-06-0192508522Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastomaMehrdad Hashemi0Sophie Mousavian Roshanzamir1Sima Orouei2Pouria Daneii3Rasoul Raesi4Haleh Zokaee5Pooria Bikarannejad6Kiana Salmani7Ramin Khorrami8Mahshid Deldar Abad Paskeh9Shokooh Salimimoghadam10Mohsen Rashidi11Kiavash Hushmandi12Afshin Taheriazam13Maliheh Entezari14Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran; Department of Health Services Management, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Oral and Maxillofacial Medicine, Dental Research Center, Golestan University of Medical Sciences, Gorgan, IranYoung Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Corresponding author. Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Corresponding author.Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding author. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.The brain tumors and especially glioblastoma, are affecting life of many people worldwide and due to their high mortality and morbidity, their treatment is of importance and has gained attention in recent years. The abnormal expression of genes is commonly observed in GBM and long non-coding RNAs (lncRNAs) have demonstrated dysregulation in this tumor. LncRNAs have length more than 200 nucleotides and they have been located in cytoplasm and nucleus. The current review focuses on the role of lncRNAs in GBM. There two types of lncRNAs in GBM including tumor-promoting and tumor-suppressor lncRNAs and overexpression of oncogenic lncRNAs increases progression of GBM. LncRNAs can regulate proliferation, cell cycle arrest and metastasis of GBM cells. Wnt, STAT3 and EZH2 are among the molecular pathways affected by lncRNAs in GBM and for regulating metastasis of GBM cells, these RNA molecules mainly affect EMT mechanism. LncRNAs are involved in drug resistance and can induce resistance of GBM cells to temozolomide chemotherapy. Furthermore, lncRNAs stimulate radio-resistance in GBM cells. LncRNAs increase PD-1 expression to mediate immune evasion. LncRNAs can be considered as diagnostic and prognostic tools in GBM and researchers have developed signature from lncRNAs in GBM.http://www.sciencedirect.com/science/article/pii/S2468054024000234LncRNAGlioblastomaDrug resistanceRadio-resistanceMetastasis |
| spellingShingle | Mehrdad Hashemi Sophie Mousavian Roshanzamir Sima Orouei Pouria Daneii Rasoul Raesi Haleh Zokaee Pooria Bikarannejad Kiana Salmani Ramin Khorrami Mahshid Deldar Abad Paskeh Shokooh Salimimoghadam Mohsen Rashidi Kiavash Hushmandi Afshin Taheriazam Maliheh Entezari Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma Non-coding RNA Research LncRNA Glioblastoma Drug resistance Radio-resistance Metastasis |
| title | Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma |
| title_full | Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma |
| title_fullStr | Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma |
| title_full_unstemmed | Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma |
| title_short | Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma |
| title_sort | shedding light on function of long non coding rnas lncrnas in glioblastoma |
| topic | LncRNA Glioblastoma Drug resistance Radio-resistance Metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000234 |
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