Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis
Background: Despite the circulating levels of PTX3 were related to the severity of various diseases, there are no studies investigating its role in patients with liver cirrhosis. We aimed to study PTX3 levels in patients with liver cirrhosis. Material and methods: A prospective cohort study included...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-09-01
|
| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119304387 |
| _version_ | 1818608179794149376 |
|---|---|
| author | Jéssica G. Pereira Telma Erotides Silva Emília T.O. Bansho Edelton F. Morato José T. Pinheiro Letícia Muraro-Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Corrêa Leonardo L. Schiavon Janaína L. Narciso-Schiavon |
| author_facet | Jéssica G. Pereira Telma Erotides Silva Emília T.O. Bansho Edelton F. Morato José T. Pinheiro Letícia Muraro-Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Corrêa Leonardo L. Schiavon Janaína L. Narciso-Schiavon |
| author_sort | Jéssica G. Pereira |
| collection | DOAJ |
| description | Background: Despite the circulating levels of PTX3 were related to the severity of various diseases, there are no studies investigating its role in patients with liver cirrhosis. We aimed to study PTX3 levels in patients with liver cirrhosis. Material and methods: A prospective cohort study included 130 patients hospitalized for acute decompensation of liver cirrhosis, 29 stable cirrhotic outpatients and 32 healthy controls evaluated in a tertiary hospital in Southern Brasil. Results: The median PTX3 level was significantly higher in stable cirrhotic patients compared to controls (2.6 vs. 1.1 ng/mL; p < 0.001), hospitalized cirrhotic patients compared to controls (3.8 vs. 1.1 ng/mL; p < 0.001), and hospitalized cirrhotic patients compared to stable cirrhotic patients (3.8 vs. 2.6 ng/ mL; p = 0.001). A positive correlation was found between PTX3 and serum creatinine (r = 0.220; p = 0.012), Chronic Liver Failure -Sequential Organ Failure Assessment score (CLIF-SOFA) (r = 0.220; p = 0.010), MELD (r = 0.279; p = 0.001) and Child-Pugh score (r = 0.224; p = 0.010). Significantly higher levels of PTX3 were observed in patients on admission with ACLF (8.9 vs. 3.1 ng/mL; p < 0.001) and MELD score ≥ 20 (6.6 vs. 3.4 ng/mL; p = 0.002). Death within 90 days occurred in 30.8% of patients and was associated with higher levels of PTX3 (5.3 vs. 3.4 ng/mL; p = 0.009). The probability of Kaplan-Meier survival was 77.0% in patients with PTX-3 < 5.3 ng mL (upper tercile) and 53.5% in those with PTX3 ≥ 5.3 ng/mL (p = 0.002). Conclusion: These results indicate the potential for use of PTX3 as an inflammatory biomarker for the prognosis of patients with hepatic cirrhosis. |
| first_indexed | 2024-12-16T14:38:32Z |
| format | Article |
| id | doaj.art-94bd8853fa9e404daba4ddac37c27e78 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:38:32Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-94bd8853fa9e404daba4ddac37c27e782022-12-21T22:28:02ZengElsevierAnnals of Hepatology1665-26812017-09-01165780787Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosisJéssica G. Pereira0Telma Erotides Silva1Emília T.O. Bansho2Edelton F. Morato3José T. Pinheiro4Letícia Muraro-Wildner5Maria Luiza Bazzo6Esther Buzaglo Dantas-Corrêa7Leonardo L. Schiavon8Janaína L. Narciso-Schiavon9Núcleo de Estudos em Gastroenterologia e Hepatologia, Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilPostgraduate Program in Medical Sciences, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina,BrazilNúcleo de Estudos em Gastroenterologia e Hepatologia, Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilCenter for Assessment of Allergic Type Reactions to Drugs, University Hospital Polydoro Ernani de São Thiago - Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilCenter for Assessment of Allergic Type Reactions to Drugs, University Hospital Polydoro Ernani de São Thiago - Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilClinical Analysis Laboratory, University Hospital Polydoro Ernani de São Thiago - Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilClinical Analysis Laboratory, University Hospital Polydoro Ernani de São Thiago - Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilNúcleo de Estudos em Gastroenterologia e Hepatologia, Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Santa Catarina, BrazilNúcleo de Estudos em Gastroenterologia e Hepatologia, Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; Postgraduate Program in Medical Sciences, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina,BrazilNúcleo de Estudos em Gastroenterologia e Hepatologia, Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; Correspondence and reprint request:Background: Despite the circulating levels of PTX3 were related to the severity of various diseases, there are no studies investigating its role in patients with liver cirrhosis. We aimed to study PTX3 levels in patients with liver cirrhosis. Material and methods: A prospective cohort study included 130 patients hospitalized for acute decompensation of liver cirrhosis, 29 stable cirrhotic outpatients and 32 healthy controls evaluated in a tertiary hospital in Southern Brasil. Results: The median PTX3 level was significantly higher in stable cirrhotic patients compared to controls (2.6 vs. 1.1 ng/mL; p < 0.001), hospitalized cirrhotic patients compared to controls (3.8 vs. 1.1 ng/mL; p < 0.001), and hospitalized cirrhotic patients compared to stable cirrhotic patients (3.8 vs. 2.6 ng/ mL; p = 0.001). A positive correlation was found between PTX3 and serum creatinine (r = 0.220; p = 0.012), Chronic Liver Failure -Sequential Organ Failure Assessment score (CLIF-SOFA) (r = 0.220; p = 0.010), MELD (r = 0.279; p = 0.001) and Child-Pugh score (r = 0.224; p = 0.010). Significantly higher levels of PTX3 were observed in patients on admission with ACLF (8.9 vs. 3.1 ng/mL; p < 0.001) and MELD score ≥ 20 (6.6 vs. 3.4 ng/mL; p = 0.002). Death within 90 days occurred in 30.8% of patients and was associated with higher levels of PTX3 (5.3 vs. 3.4 ng/mL; p = 0.009). The probability of Kaplan-Meier survival was 77.0% in patients with PTX-3 < 5.3 ng mL (upper tercile) and 53.5% in those with PTX3 ≥ 5.3 ng/mL (p = 0.002). Conclusion: These results indicate the potential for use of PTX3 as an inflammatory biomarker for the prognosis of patients with hepatic cirrhosis.http://www.sciencedirect.com/science/article/pii/S1665268119304387Liver cirrhosisInflammationBiomarkersPTX3 proteinPrognosisAcute-On-Chronic Liver Failure |
| spellingShingle | Jéssica G. Pereira Telma Erotides Silva Emília T.O. Bansho Edelton F. Morato José T. Pinheiro Letícia Muraro-Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Corrêa Leonardo L. Schiavon Janaína L. Narciso-Schiavon Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis Annals of Hepatology Liver cirrhosis Inflammation Biomarkers PTX3 protein Prognosis Acute-On-Chronic Liver Failure |
| title | Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis |
| title_full | Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis |
| title_fullStr | Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis |
| title_full_unstemmed | Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis |
| title_short | Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis |
| title_sort | circulating levels of pentraxin 3 ptx3 in patients with liver cirrhosis |
| topic | Liver cirrhosis Inflammation Biomarkers PTX3 protein Prognosis Acute-On-Chronic Liver Failure |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119304387 |
| work_keys_str_mv | AT jessicagpereira circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT telmaerotidessilva circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT emiliatobansho circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT edeltonfmorato circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT josetpinheiro circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT leticiamurarowildner circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT marialuizabazzo circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT estherbuzaglodantascorrea circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT leonardolschiavon circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis AT janainalnarcisoschiavon circulatinglevelsofpentraxin3ptx3inpatientswithlivercirrhosis |