Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
Background : Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. Materials and Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. Result: Patients w...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=9;spage=882;epage=885;aulast=Foroughipour |
| _version_ | 1818096458342072320 |
|---|---|
| author | Azam Foroughipour Vajihe Norbakhsh Sara Hosseinpour Najafabadi Rokhsareh Meamar |
| author_facet | Azam Foroughipour Vajihe Norbakhsh Sara Hosseinpour Najafabadi Rokhsareh Meamar |
| author_sort | Azam Foroughipour |
| collection | DOAJ |
| description | Background : Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. Materials and Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. Result: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. Conclusion: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease. |
| first_indexed | 2024-12-10T23:04:57Z |
| format | Article |
| id | doaj.art-94bddbbb692d4d12903700197b53b9ee |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-10T23:04:57Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-94bddbbb692d4d12903700197b53b9ee2022-12-22T01:30:03ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362012-01-01179882885Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severityAzam ForoughipourVajihe NorbakhshSara Hosseinpour NajafabadiRokhsareh MeamarBackground : Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. Materials and Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. Result: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. Conclusion: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=9;spage=882;epage=885;aulast=ForoughipourDisease severityestradiolhormonesmultiple sclerosisprogesteronetestosteronewomen |
| spellingShingle | Azam Foroughipour Vajihe Norbakhsh Sara Hosseinpour Najafabadi Rokhsareh Meamar Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity Journal of Research in Medical Sciences Disease severity estradiol hormones multiple sclerosis progesterone testosterone women |
| title | Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| title_full | Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| title_fullStr | Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| title_full_unstemmed | Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| title_short | Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| title_sort | evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity |
| topic | Disease severity estradiol hormones multiple sclerosis progesterone testosterone women |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=9;spage=882;epage=885;aulast=Foroughipour |
| work_keys_str_mv | AT azamforoughipour evaluatingsexhormonelevelsinreproductiveagewomenwithmultiplesclerosisandtheirrelationshipwithdiseaseseverity AT vajihenorbakhsh evaluatingsexhormonelevelsinreproductiveagewomenwithmultiplesclerosisandtheirrelationshipwithdiseaseseverity AT sarahosseinpournajafabadi evaluatingsexhormonelevelsinreproductiveagewomenwithmultiplesclerosisandtheirrelationshipwithdiseaseseverity AT rokhsarehmeamar evaluatingsexhormonelevelsinreproductiveagewomenwithmultiplesclerosisandtheirrelationshipwithdiseaseseverity |