Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth
Stomatin is a component of lipid rafts. Here, Wu et al. show that stomatin modulates the differentiation and functions of adipocytes by regulating adipogenesis signaling and fatty acid influx such that with excessive calorie intake, increased stomatin induces adiposity.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31825-z |
| _version_ | 1811287129194496000 |
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| author | Shao-Chin Wu Yuan-Ming Lo Jui-Hao Lee Chin-Yau Chen Tung-Wei Chen Hong-Wen Liu Wei-Nan Lian Kate Hua Chen-Chung Liao Wei-Ju Lin Chih-Yung Yang Chien-Yi Tung Chi-Hung Lin |
| author_facet | Shao-Chin Wu Yuan-Ming Lo Jui-Hao Lee Chin-Yau Chen Tung-Wei Chen Hong-Wen Liu Wei-Nan Lian Kate Hua Chen-Chung Liao Wei-Ju Lin Chih-Yung Yang Chien-Yi Tung Chi-Hung Lin |
| author_sort | Shao-Chin Wu |
| collection | DOAJ |
| description | Stomatin is a component of lipid rafts. Here, Wu et al. show that stomatin modulates the differentiation and functions of adipocytes by regulating adipogenesis signaling and fatty acid influx such that with excessive calorie intake, increased stomatin induces adiposity. |
| first_indexed | 2024-04-13T03:12:11Z |
| format | Article |
| id | doaj.art-94be8866866445c382b2abbb4e47032c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T03:12:11Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-94be8866866445c382b2abbb4e47032c2022-12-22T03:05:00ZengNature PortfolioNature Communications2041-17232022-07-0113111710.1038/s41467-022-31825-zStomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growthShao-Chin Wu0Yuan-Ming Lo1Jui-Hao Lee2Chin-Yau Chen3Tung-Wei Chen4Hong-Wen Liu5Wei-Nan Lian6Kate Hua7Chen-Chung Liao8Wei-Ju Lin9Chih-Yung Yang10Chien-Yi Tung11Chi-Hung Lin12Institute of Biophotonics, National Yang Ming Chiao Tung UniversityInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung UniversityTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia SinicaDepartment of Surgery, National Yang Ming Chiao Tung University HospitalInstitute of Biophotonics, National Yang Ming Chiao Tung UniversityChong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang Ming Chiao Tung UniversityInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung UniversityGenomics Center for Clinical and Biotechnological Applications, Cancer Progression Research Center, National Yang Ming Chiao Tung UniversityGenomics Center for Clinical and Biotechnological Applications, Cancer Progression Research Center, National Yang Ming Chiao Tung UniversityGenomics Center for Clinical and Biotechnological Applications, Cancer Progression Research Center, National Yang Ming Chiao Tung UniversityDepartment of Education and Research, Taipei City HospitalGenomics Center for Clinical and Biotechnological Applications, Cancer Progression Research Center, National Yang Ming Chiao Tung UniversityInstitute of Biophotonics, National Yang Ming Chiao Tung UniversityStomatin is a component of lipid rafts. Here, Wu et al. show that stomatin modulates the differentiation and functions of adipocytes by regulating adipogenesis signaling and fatty acid influx such that with excessive calorie intake, increased stomatin induces adiposity.https://doi.org/10.1038/s41467-022-31825-z |
| spellingShingle | Shao-Chin Wu Yuan-Ming Lo Jui-Hao Lee Chin-Yau Chen Tung-Wei Chen Hong-Wen Liu Wei-Nan Lian Kate Hua Chen-Chung Liao Wei-Ju Lin Chih-Yung Yang Chien-Yi Tung Chi-Hung Lin Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth Nature Communications |
| title | Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth |
| title_full | Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth |
| title_fullStr | Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth |
| title_full_unstemmed | Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth |
| title_short | Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth |
| title_sort | stomatin modulates adipogenesis through the erk pathway and regulates fatty acid uptake and lipid droplet growth |
| url | https://doi.org/10.1038/s41467-022-31825-z |
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