Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men

Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men

Bone marrow adipose tissue (MAT) is influenced by nutritional cues, and participates in whole body energy metabolism. To investigate the role of Sirtuin1 (Sirt1), a key player in metabolism, in MAT, marrow adiposity was evaluated in inbred 5-month-old 129/Sv Sirt1 haplo-insufficient (Sirt1Δ/+) and w...

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Bibliographic Details
Main Authors: Hanna Artsi, Irina Gurt, Madi El-Haj, Ralph Müller, Gisela A. Kuhn, Gal Ben Shalom, Einav Cohen-Kfir, Eva Abramowitz, Leonid Kandel, Ori Safran, Rivka Dresner-Pollak
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
sirtuin1
marrow adipose tissue
PGC1-alpha
bone marrow mesenchymal stem cells
thermogenic genes
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00126/full

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