Exercise and epigenetic ages in older adults with myeloid malignancies
Abstract Background Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, canc...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01145-z |
| _version_ | 1797811559589740544 |
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| author | Kah Poh Loh Chandrika Sanapala Marielle Jensen-Battaglia Anish Rana Michael B. Sohn Erin Watson Nikesha Gilmore Heidi D. Klepin Jason H. Mendler Jane Liesveld Eric Huselton Marissa LoCastro Martha Susiarjo Colleen Netherby-Winslow AnnaLynn M. Williams Karen Mustian Paula Vertino Michelle C. Janelsins |
| author_facet | Kah Poh Loh Chandrika Sanapala Marielle Jensen-Battaglia Anish Rana Michael B. Sohn Erin Watson Nikesha Gilmore Heidi D. Klepin Jason H. Mendler Jane Liesveld Eric Huselton Marissa LoCastro Martha Susiarjo Colleen Netherby-Winslow AnnaLynn M. Williams Karen Mustian Paula Vertino Michelle C. Janelsins |
| author_sort | Kah Poh Loh |
| collection | DOAJ |
| description | Abstract Background Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age. We explored (1) the associations of accelerated DNAm age with physical, psychological, and cognitive functions at baseline; (2) changes in DNAm age from baseline to post-intervention; and (3) the associations of changes in accelerated DNAm age with changes in functions from baseline to post-intervention. Methods We enrolled older patients with myeloid malignancies to a single-arm pilot study testing a mobile health (mHealth) exercise intervention that combines an exercise program (EXCAP©®) with a mobile application over 2 cycles of chemotherapy (8–12 weeks). Patients completed measures of physical, psychological, and cognitive functions and provided blood samples for analyses of DNAm age at baseline and post-intervention. Paired t-tests or Wilcoxon signed rank tests assessed changes in DNAm ages, and Spearman’s correlation assessed the relationships between accelerated ages and functions. Results We included 20 patients (mean age: 72 years, range 62–80). Accelerated GrimAge, accelerated PhenoAge, and DunedinPACE were stable from baseline to post-intervention. At baseline, DunedinPACE was correlated with worse grip strength (r = -0.41, p = 0.08). From baseline to post-intervention, decreases in accelerated GrimAge (r = -0.50, p = 0.02), accelerated PhenoAge (r = − 0.39, p = 0.09), and DunedinPace (r = − 0.43, p = 0.06) were correlated with increases in distance walked on 6-min walk test. Decreases in accelerated GrimAge (r = − 0.49, p = 0.03), accelerated PhenoAge (r = − 0.40, p = 0.08), and DunedinPace (r = − 0.41, p = 0.07) were correlated with increases in in grip strength. Conclusions Among older adults with myeloid malignancies receiving chemotherapy, GrimAge and PhenoAge on average are stable after a mHealth exercise intervention. Decreases in accelerated GrimAge, accelerated PhenoAge, and DunedinPACE over 8–12 weeks of exercise were correlated with increased physical performance. Future trials assessing the effects of exercise on treatment-related toxicities should evaluate DNAm age. Trial registration Clinicaltrials.gov identifier: NCT04981821. |
| first_indexed | 2024-03-13T07:25:33Z |
| format | Article |
| id | doaj.art-94c15e53c0a8487788c69f26cd8fc038 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-13T07:25:33Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-94c15e53c0a8487788c69f26cd8fc0382023-06-04T11:24:20ZengBMCEuropean Journal of Medical Research2047-783X2023-05-0128111210.1186/s40001-023-01145-zExercise and epigenetic ages in older adults with myeloid malignanciesKah Poh Loh0Chandrika Sanapala1Marielle Jensen-Battaglia2Anish Rana3Michael B. Sohn4Erin Watson5Nikesha Gilmore6Heidi D. Klepin7Jason H. Mendler8Jane Liesveld9Eric Huselton10Marissa LoCastro11Martha Susiarjo12Colleen Netherby-Winslow13AnnaLynn M. Williams14Karen Mustian15Paula Vertino16Michelle C. Janelsins17James P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteDepartment of Public Health Sciences, University of Rochester Medical CenterSchool of Medicine and Dentistry, University of RochesterDepartment of Biostatistics and Computational Biology, University of Rochester Medical CenterDepartment of Psychology, Princeton UniversityDivision of Cancer Control, Department of Surgery, University of Rochester Medical CenterWake Forest Baptist Comprehensive Cancer Center, Medical Center BlvdJames P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteDepartment of Environmental Medicine, University of Rochester Medical CenterDivision of Cancer Control, Department of Surgery, University of Rochester Medical CenterDivision of Cancer Control, Department of Surgery, University of Rochester Medical CenterJames P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteJames P. Wilmot Cancer InstituteAbstract Background Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age. We explored (1) the associations of accelerated DNAm age with physical, psychological, and cognitive functions at baseline; (2) changes in DNAm age from baseline to post-intervention; and (3) the associations of changes in accelerated DNAm age with changes in functions from baseline to post-intervention. Methods We enrolled older patients with myeloid malignancies to a single-arm pilot study testing a mobile health (mHealth) exercise intervention that combines an exercise program (EXCAP©®) with a mobile application over 2 cycles of chemotherapy (8–12 weeks). Patients completed measures of physical, psychological, and cognitive functions and provided blood samples for analyses of DNAm age at baseline and post-intervention. Paired t-tests or Wilcoxon signed rank tests assessed changes in DNAm ages, and Spearman’s correlation assessed the relationships between accelerated ages and functions. Results We included 20 patients (mean age: 72 years, range 62–80). Accelerated GrimAge, accelerated PhenoAge, and DunedinPACE were stable from baseline to post-intervention. At baseline, DunedinPACE was correlated with worse grip strength (r = -0.41, p = 0.08). From baseline to post-intervention, decreases in accelerated GrimAge (r = -0.50, p = 0.02), accelerated PhenoAge (r = − 0.39, p = 0.09), and DunedinPace (r = − 0.43, p = 0.06) were correlated with increases in distance walked on 6-min walk test. Decreases in accelerated GrimAge (r = − 0.49, p = 0.03), accelerated PhenoAge (r = − 0.40, p = 0.08), and DunedinPace (r = − 0.41, p = 0.07) were correlated with increases in in grip strength. Conclusions Among older adults with myeloid malignancies receiving chemotherapy, GrimAge and PhenoAge on average are stable after a mHealth exercise intervention. Decreases in accelerated GrimAge, accelerated PhenoAge, and DunedinPACE over 8–12 weeks of exercise were correlated with increased physical performance. Future trials assessing the effects of exercise on treatment-related toxicities should evaluate DNAm age. Trial registration Clinicaltrials.gov identifier: NCT04981821.https://doi.org/10.1186/s40001-023-01145-zDNA methylationEpigenetic clockMobile healthExercise interventionGeriatric hematologyMyeloid malignancies |
| spellingShingle | Kah Poh Loh Chandrika Sanapala Marielle Jensen-Battaglia Anish Rana Michael B. Sohn Erin Watson Nikesha Gilmore Heidi D. Klepin Jason H. Mendler Jane Liesveld Eric Huselton Marissa LoCastro Martha Susiarjo Colleen Netherby-Winslow AnnaLynn M. Williams Karen Mustian Paula Vertino Michelle C. Janelsins Exercise and epigenetic ages in older adults with myeloid malignancies European Journal of Medical Research DNA methylation Epigenetic clock Mobile health Exercise intervention Geriatric hematology Myeloid malignancies |
| title | Exercise and epigenetic ages in older adults with myeloid malignancies |
| title_full | Exercise and epigenetic ages in older adults with myeloid malignancies |
| title_fullStr | Exercise and epigenetic ages in older adults with myeloid malignancies |
| title_full_unstemmed | Exercise and epigenetic ages in older adults with myeloid malignancies |
| title_short | Exercise and epigenetic ages in older adults with myeloid malignancies |
| title_sort | exercise and epigenetic ages in older adults with myeloid malignancies |
| topic | DNA methylation Epigenetic clock Mobile health Exercise intervention Geriatric hematology Myeloid malignancies |
| url | https://doi.org/10.1186/s40001-023-01145-z |
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