Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic
Svetlana I Kolesnichenko,1,* Irina A Kadyrova,1 Alyona V Lavrinenko,1 Zhibek A Zhumadilova,1 Olga V Avdienko,1 Yelena V Vinogradskaya,2 Yevgeniy A Fominykh,3 Lyudmila G Panibratec,3 Lyudmila L Akhmaltdinova1,4,* 1Shared Resource Laboratory, Research Centre, Karaganda Medical Universi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-10-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/mortality-risk-factors-of-early-neonatal-sepsis-during-covid-19-pandem-peer-reviewed-fulltext-article-IDR |
| _version_ | 1811333284701929472 |
|---|---|
| author | Kolesnichenko SI Kadyrova IA Lavrinenko AV Zhumadilova ZA Avdienko OV Vinogradskaya YV Fominykh YA Panibratec LG Akhmaltdinova LL |
| author_facet | Kolesnichenko SI Kadyrova IA Lavrinenko AV Zhumadilova ZA Avdienko OV Vinogradskaya YV Fominykh YA Panibratec LG Akhmaltdinova LL |
| author_sort | Kolesnichenko SI |
| collection | DOAJ |
| description | Svetlana I Kolesnichenko,1,* Irina A Kadyrova,1 Alyona V Lavrinenko,1 Zhibek A Zhumadilova,1 Olga V Avdienko,1 Yelena V Vinogradskaya,2 Yevgeniy A Fominykh,3 Lyudmila G Panibratec,3 Lyudmila L Akhmaltdinova1,4,* 1Shared Resource Laboratory, Research Centre, Karaganda Medical University, Karaganda, Kazakhstan; 2Regional Clinical Hospital of Karaganda, Perinatal Center No. 1, Karaganda, Kazakhstan; 3Regional Clinical Hospital of Karaganda, Perinatal Center No. 2, Karaganda, Kazakhstan; 4National Scientific Cardiac Surgery Center, Nur-Sultan, Kazakhstan*These authors contributed equally to this workCorrespondence: Svetlana I Kolesnichenko, Shared Resource Laboratory, Research Centre, Karaganda Medical University, 40 Gogol St, Karaganda, 100008, Kazakhstan, Tel +7 702 599 0225, Email kolesnichenko@kgmu.kzPurpose: This study aimed to determine predisposing factors for negative outcome in infants with early neonatal sepsis during COVID-19.Patients and Methods: A prospective cohort study of 172 newborns up to 4 days diagnosed with neonatal sepsis was carried out in Karaganda (Kazakhstan). The microbiological examination was used to identify a causative agent of bloodstream infection. ELISA was performed to determine the total anti-SARS-CoV-2 antibodies. Gestational age, mode of delivery, birth weight, C-reactive protein and procalcitonin levels, comorbidities, type of pathogen, duration of hospitalization and mother’s infection diseases were used for statistical analysis.Results: Mortality in infants with neonatal sepsis was 22% (38/172). Anti-SARS-CoV-2 antibodies were detected in 68.3% of the newborns. Culture-negative ELBW infants have a 5.3-fold higher risk of death (p< 0.001). Low gestational age and a shorter period of hospitalization were statistically associated with fatality. CRP is generally higher in deceased children (p=0.002). Necrotizing enterocolitis (p< 0.001), pneumonia (p=0.009) and anemia (p=0.016) were significantly associated with negative outcome. And, 31.4% of the infants with sepsis had positive blood cultures. The leading cause of sepsis in newborns was CoNS – 57%.Conclusion: During COVID-19 pandemic neonatal sepsis mortality was associated with low birth weight, gestational age, and comorbidities as in non-pandemic time. The relationship between COVID-19 in the mother and neonatal mortality was not found. However, anti-SARS-CoV-2 antibodies were detected in more than half of newborns.Keywords: neonatal sepsis, preterm infants, mortality, coagulase-negative staphylococci, COVID-19 |
| first_indexed | 2024-04-13T16:50:13Z |
| format | Article |
| id | doaj.art-94c2415831624d7f905b074189c8212d |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T16:50:13Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-94c2415831624d7f905b074189c8212d2022-12-22T02:38:58ZengDove Medical PressInfection and Drug Resistance1178-69732022-10-01Volume 156307631679328Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 PandemicKolesnichenko SIKadyrova IALavrinenko AVZhumadilova ZAAvdienko OVVinogradskaya YVFominykh YAPanibratec LGAkhmaltdinova LLSvetlana I Kolesnichenko,1,* Irina A Kadyrova,1 Alyona V Lavrinenko,1 Zhibek A Zhumadilova,1 Olga V Avdienko,1 Yelena V Vinogradskaya,2 Yevgeniy A Fominykh,3 Lyudmila G Panibratec,3 Lyudmila L Akhmaltdinova1,4,* 1Shared Resource Laboratory, Research Centre, Karaganda Medical University, Karaganda, Kazakhstan; 2Regional Clinical Hospital of Karaganda, Perinatal Center No. 1, Karaganda, Kazakhstan; 3Regional Clinical Hospital of Karaganda, Perinatal Center No. 2, Karaganda, Kazakhstan; 4National Scientific Cardiac Surgery Center, Nur-Sultan, Kazakhstan*These authors contributed equally to this workCorrespondence: Svetlana I Kolesnichenko, Shared Resource Laboratory, Research Centre, Karaganda Medical University, 40 Gogol St, Karaganda, 100008, Kazakhstan, Tel +7 702 599 0225, Email kolesnichenko@kgmu.kzPurpose: This study aimed to determine predisposing factors for negative outcome in infants with early neonatal sepsis during COVID-19.Patients and Methods: A prospective cohort study of 172 newborns up to 4 days diagnosed with neonatal sepsis was carried out in Karaganda (Kazakhstan). The microbiological examination was used to identify a causative agent of bloodstream infection. ELISA was performed to determine the total anti-SARS-CoV-2 antibodies. Gestational age, mode of delivery, birth weight, C-reactive protein and procalcitonin levels, comorbidities, type of pathogen, duration of hospitalization and mother’s infection diseases were used for statistical analysis.Results: Mortality in infants with neonatal sepsis was 22% (38/172). Anti-SARS-CoV-2 antibodies were detected in 68.3% of the newborns. Culture-negative ELBW infants have a 5.3-fold higher risk of death (p< 0.001). Low gestational age and a shorter period of hospitalization were statistically associated with fatality. CRP is generally higher in deceased children (p=0.002). Necrotizing enterocolitis (p< 0.001), pneumonia (p=0.009) and anemia (p=0.016) were significantly associated with negative outcome. And, 31.4% of the infants with sepsis had positive blood cultures. The leading cause of sepsis in newborns was CoNS – 57%.Conclusion: During COVID-19 pandemic neonatal sepsis mortality was associated with low birth weight, gestational age, and comorbidities as in non-pandemic time. The relationship between COVID-19 in the mother and neonatal mortality was not found. However, anti-SARS-CoV-2 antibodies were detected in more than half of newborns.Keywords: neonatal sepsis, preterm infants, mortality, coagulase-negative staphylococci, COVID-19https://www.dovepress.com/mortality-risk-factors-of-early-neonatal-sepsis-during-covid-19-pandem-peer-reviewed-fulltext-article-IDRneonatal sepsispreterm infantsmortalitycoagulase-negative staphylococcicovid-19 |
| spellingShingle | Kolesnichenko SI Kadyrova IA Lavrinenko AV Zhumadilova ZA Avdienko OV Vinogradskaya YV Fominykh YA Panibratec LG Akhmaltdinova LL Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic Infection and Drug Resistance neonatal sepsis preterm infants mortality coagulase-negative staphylococci covid-19 |
| title | Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic |
| title_full | Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic |
| title_fullStr | Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic |
| title_full_unstemmed | Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic |
| title_short | Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic |
| title_sort | mortality risk factors of early neonatal sepsis during covid 19 pandemic |
| topic | neonatal sepsis preterm infants mortality coagulase-negative staphylococci covid-19 |
| url | https://www.dovepress.com/mortality-risk-factors-of-early-neonatal-sepsis-during-covid-19-pandem-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT kolesnichenkosi mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT kadyrovaia mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT lavrinenkoav mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT zhumadilovaza mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT avdienkoov mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT vinogradskayayv mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT fominykhya mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT panibrateclg mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic AT akhmaltdinovall mortalityriskfactorsofearlyneonatalsepsisduringcovid19pandemic |