Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study
Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-11-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867011702471 |
| _version_ | 1818204949075460096 |
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| author | Maria José Penna Maisonnette de Attayde Silva, MSc Student Gilzandra Lira Dantas Florêncio, MSc Student José Roberto Erbolato Gabiatti, PhD Rose Luce do Amaral, PhD in Tocoginecology, UNICAMP José Eleutério Júnior, PhD in Ginecology, UNICAMP Ana Katherine da Silveira Gonçalves, PhD, UNICAMP |
| author_facet | Maria José Penna Maisonnette de Attayde Silva, MSc Student Gilzandra Lira Dantas Florêncio, MSc Student José Roberto Erbolato Gabiatti, PhD Rose Luce do Amaral, PhD in Tocoginecology, UNICAMP José Eleutério Júnior, PhD in Ginecology, UNICAMP Ana Katherine da Silveira Gonçalves, PhD, UNICAMP |
| author_sort | Maria José Penna Maisonnette de Attayde Silva, MSc Student |
| collection | DOAJ |
| description | Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. Results: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). Conclusion: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings. Keywords: Chlamydia trachomatis, perinatal mortality, morbidity, meta-analysis |
| first_indexed | 2024-12-12T03:49:21Z |
| format | Article |
| id | doaj.art-94c33d21a26946dc8aee387a3e588ca6 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-12T03:49:21Z |
| publishDate | 2011-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-94c33d21a26946dc8aee387a3e588ca62022-12-22T00:39:27ZengElsevierBrazilian Journal of Infectious Diseases1413-86702011-11-01156533539Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis studyMaria José Penna Maisonnette de Attayde Silva, MSc Student0Gilzandra Lira Dantas Florêncio, MSc Student1José Roberto Erbolato Gabiatti, PhD2Rose Luce do Amaral, PhD in Tocoginecology, UNICAMP3José Eleutério Júnior, PhD in Ginecology, UNICAMP4Ana Katherine da Silveira Gonçalves, PhD, UNICAMP5Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte (UFRN); Universidade Potiguar (UnP), RN, BrazilPostgraduate Program in Health Sciences, UFRN, RN, BrazilTocoginecology Department, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM-UNICAMP), SP, BrazilUNICAMP, SP, BrazilUniversidade Federal do Ceará (UFC), CE,BrazilUFRN, RN, Brazil; Correspondence to: Rua Major Laurentino de Morais, 1218/1301 59020-390 – Natal, SP, Brazil Phone: +55 84 36154160.Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. Results: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). Conclusion: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings. Keywords: Chlamydia trachomatis, perinatal mortality, morbidity, meta-analysishttp://www.sciencedirect.com/science/article/pii/S1413867011702471 |
| spellingShingle | Maria José Penna Maisonnette de Attayde Silva, MSc Student Gilzandra Lira Dantas Florêncio, MSc Student José Roberto Erbolato Gabiatti, PhD Rose Luce do Amaral, PhD in Tocoginecology, UNICAMP José Eleutério Júnior, PhD in Ginecology, UNICAMP Ana Katherine da Silveira Gonçalves, PhD, UNICAMP Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study Brazilian Journal of Infectious Diseases |
| title | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_full | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_fullStr | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_full_unstemmed | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_short | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_sort | perinatal morbidity and mortality associated with chlamydial infection a meta analysis study |
| url | http://www.sciencedirect.com/science/article/pii/S1413867011702471 |
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