The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis
Background: Studies have established that sex and age influence outcomes following out-of-hospital cardiac arrest (OHCA). However, a knowledge gap exists regarding their interaction. This study aimed to investigate the interaction of age and sex and how they cooperatively influence OHCA outcomes. Me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Resuscitation Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520424000031 |
| _version_ | 1797242964236304384 |
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| author | Ching-Yu Chen Cheng-Yi Fan I-Chung Chen Yun-Chang Chen Ming-Tai Cheng Wen‑Chu Chiang Chien-Hua Huang Chih-Wei Sung Edward Pei-Chuan Huang |
| author_facet | Ching-Yu Chen Cheng-Yi Fan I-Chung Chen Yun-Chang Chen Ming-Tai Cheng Wen‑Chu Chiang Chien-Hua Huang Chih-Wei Sung Edward Pei-Chuan Huang |
| author_sort | Ching-Yu Chen |
| collection | DOAJ |
| description | Background: Studies have established that sex and age influence outcomes following out-of-hospital cardiac arrest (OHCA). However, a knowledge gap exists regarding their interaction. This study aimed to investigate the interaction of age and sex and how they cooperatively influence OHCA outcomes. Methods: This retrospective cohort study included adult, nontraumatic OHCA patients admitted to a university hospital and its affiliated hospitals in Taiwan from January 2017 to December 2021. Data including sex, age, body mass index, cardiac rhythm, and resuscitation information in the emergency department (ED) were collected from medical records. The study outcomes encompassed survival to intensive care unit (ICU) admission, survival to hospital discharge, and a favorable neurological outcome. Multivariable logistic regression was performed to estimate the influence of sex on study outcomes. Results: We analyzed a total of 2,826 eligible subjects categorized into three groups: young (18–44 years, 149 males and 57 females), middle-aged (45–64 years, 524 males and 188 females), and old (≥65 years, 1,049 males and 859 females). Analysis of the effects of sex according to age stratification showed that old males had higher odds for survival to ICU admission (OR: 1.49, 95% CI: 1.21–1.83) and favorable neurological outcomes (OR: 2.74, 95% CI: 1.58–4.76) than did old females. Analysis of the effects of age according to sex stratification revealed that old males had lower odds for survival to hospital discharge (OR: 0.33, 95% CI: 0.21–0.51) and favorable neurological outcomes (OR: 0.26, 95% CI: 0.16–0.43) than did young males. Old females also showed the same trend as males, with lower odds for survival to hospital discharge (OR: 0.37, 95% CI: 0.17–0.78) and favorable neurological outcomes (OR: 0.11, 95% CI: 0.05–0.25) than did young females. Conclusions: The interaction between sex and age in patients with OHCA results in diverse outcomes. Within the same sex, age demonstrated varying effects on distinct outcomes. |
| first_indexed | 2024-03-08T12:47:29Z |
| format | Article |
| id | doaj.art-94c57f82fa65492f8df3491950169c49 |
| institution | Directory Open Access Journal |
| issn | 2666-5204 |
| language | English |
| last_indexed | 2024-04-24T18:47:35Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj.art-94c57f82fa65492f8df3491950169c492024-03-27T04:53:03ZengElsevierResuscitation Plus2666-52042024-03-0117100552The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysisChing-Yu Chen0Cheng-Yi Fan1I-Chung Chen2Yun-Chang Chen3Ming-Tai Cheng4Wen‑Chu Chiang5Chien-Hua Huang6Chih-Wei Sung7Edward Pei-Chuan Huang8Department of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliu, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliu, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliu, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliu, Taiwan; Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliu, Taiwan; Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding authors at: Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, No.25, Lane 442, Sec.1, Jingguo Rd, Hsinchu City 300, Taiwan.Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan; Corresponding authors at: Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, No.25, Lane 442, Sec.1, Jingguo Rd, Hsinchu City 300, Taiwan.Background: Studies have established that sex and age influence outcomes following out-of-hospital cardiac arrest (OHCA). However, a knowledge gap exists regarding their interaction. This study aimed to investigate the interaction of age and sex and how they cooperatively influence OHCA outcomes. Methods: This retrospective cohort study included adult, nontraumatic OHCA patients admitted to a university hospital and its affiliated hospitals in Taiwan from January 2017 to December 2021. Data including sex, age, body mass index, cardiac rhythm, and resuscitation information in the emergency department (ED) were collected from medical records. The study outcomes encompassed survival to intensive care unit (ICU) admission, survival to hospital discharge, and a favorable neurological outcome. Multivariable logistic regression was performed to estimate the influence of sex on study outcomes. Results: We analyzed a total of 2,826 eligible subjects categorized into three groups: young (18–44 years, 149 males and 57 females), middle-aged (45–64 years, 524 males and 188 females), and old (≥65 years, 1,049 males and 859 females). Analysis of the effects of sex according to age stratification showed that old males had higher odds for survival to ICU admission (OR: 1.49, 95% CI: 1.21–1.83) and favorable neurological outcomes (OR: 2.74, 95% CI: 1.58–4.76) than did old females. Analysis of the effects of age according to sex stratification revealed that old males had lower odds for survival to hospital discharge (OR: 0.33, 95% CI: 0.21–0.51) and favorable neurological outcomes (OR: 0.26, 95% CI: 0.16–0.43) than did young males. Old females also showed the same trend as males, with lower odds for survival to hospital discharge (OR: 0.37, 95% CI: 0.17–0.78) and favorable neurological outcomes (OR: 0.11, 95% CI: 0.05–0.25) than did young females. Conclusions: The interaction between sex and age in patients with OHCA results in diverse outcomes. Within the same sex, age demonstrated varying effects on distinct outcomes.http://www.sciencedirect.com/science/article/pii/S2666520424000031Out-of-hospital cardiac arrestOutcomeAgeSexInteraction |
| spellingShingle | Ching-Yu Chen Cheng-Yi Fan I-Chung Chen Yun-Chang Chen Ming-Tai Cheng Wen‑Chu Chiang Chien-Hua Huang Chih-Wei Sung Edward Pei-Chuan Huang The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis Resuscitation Plus Out-of-hospital cardiac arrest Outcome Age Sex Interaction |
| title | The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis |
| title_full | The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis |
| title_fullStr | The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis |
| title_full_unstemmed | The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis |
| title_short | The interaction of sex and age on outcomes in emergency medical services-treated out-of-hospital cardiac arrest: A 5-year multicenter retrospective analysis |
| title_sort | interaction of sex and age on outcomes in emergency medical services treated out of hospital cardiac arrest a 5 year multicenter retrospective analysis |
| topic | Out-of-hospital cardiac arrest Outcome Age Sex Interaction |
| url | http://www.sciencedirect.com/science/article/pii/S2666520424000031 |
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