Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension
Background and aimsEvidence indicates that serum Klotho concentration is associated with mortality in patients with chronic kidney disease (CKD). However, evidence on this association among people with hypertension is scarce. Therefore, we aimed to examine the association between serum Klotho concen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013747/full |
| _version_ | 1811220867240165376 |
|---|---|
| author | Yuqin Yan Jun Chen |
| author_facet | Yuqin Yan Jun Chen |
| author_sort | Yuqin Yan |
| collection | DOAJ |
| description | Background and aimsEvidence indicates that serum Klotho concentration is associated with mortality in patients with chronic kidney disease (CKD). However, evidence on this association among people with hypertension is scarce. Therefore, we aimed to examine the association between serum Klotho concentration and all-cause and cardiovascular mortality in American patients with hypertension.Methods and resultsWe included 6,778 participants with hypertension from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. A Cox proportional hazard model was used to compute the hazard ratios (HRs) and 95% confidence intervals (CIs). The correlation between serum Klotho concentration and mortality was determined using restricted cubic spline and piecewise linear regression analyses. During 36,714 person-years of follow-up, 575 deaths were documented. Lower serum Klotho concentration was associated with increased all-cause mortality, but not cardiovascular mortality after multivariate adjustment. According to spline analysis, the correlation between serum Klotho concentration and all-cause mortality was non-linear (P < 0.001), and the threshold value was 574 pg/mL. The HR below the threshold point was 0.79 (95% CI: 0.67–0.93); no significant difference was found above the threshold point.ConclusionHigher serum Klotho concentration was associated with lower all-cause mortality, but not cardiovascular mortality in patients with hypertension with or without chronic renal impairment. |
| first_indexed | 2024-04-12T07:50:06Z |
| format | Article |
| id | doaj.art-94c789c48ec049d1b77e8082e2a7b6b5 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T07:50:06Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-94c789c48ec049d1b77e8082e2a7b6b52022-12-22T03:41:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10137471013747Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertensionYuqin YanJun ChenBackground and aimsEvidence indicates that serum Klotho concentration is associated with mortality in patients with chronic kidney disease (CKD). However, evidence on this association among people with hypertension is scarce. Therefore, we aimed to examine the association between serum Klotho concentration and all-cause and cardiovascular mortality in American patients with hypertension.Methods and resultsWe included 6,778 participants with hypertension from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. A Cox proportional hazard model was used to compute the hazard ratios (HRs) and 95% confidence intervals (CIs). The correlation between serum Klotho concentration and mortality was determined using restricted cubic spline and piecewise linear regression analyses. During 36,714 person-years of follow-up, 575 deaths were documented. Lower serum Klotho concentration was associated with increased all-cause mortality, but not cardiovascular mortality after multivariate adjustment. According to spline analysis, the correlation between serum Klotho concentration and all-cause mortality was non-linear (P < 0.001), and the threshold value was 574 pg/mL. The HR below the threshold point was 0.79 (95% CI: 0.67–0.93); no significant difference was found above the threshold point.ConclusionHigher serum Klotho concentration was associated with lower all-cause mortality, but not cardiovascular mortality in patients with hypertension with or without chronic renal impairment.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013747/fullblood pressurecardiovascular diseasechronic kidney diseasehypertensionKlothoCenters for Disease Control and Prevention |
| spellingShingle | Yuqin Yan Jun Chen Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension Frontiers in Cardiovascular Medicine blood pressure cardiovascular disease chronic kidney disease hypertension Klotho Centers for Disease Control and Prevention |
| title | Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension |
| title_full | Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension |
| title_fullStr | Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension |
| title_full_unstemmed | Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension |
| title_short | Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension |
| title_sort | association between serum klotho concentration and all cause and cardiovascular mortality among american individuals with hypertension |
| topic | blood pressure cardiovascular disease chronic kidney disease hypertension Klotho Centers for Disease Control and Prevention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013747/full |
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