Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia

Dementia is a major public health concern nowadays. Reduced levels of brain docosahexaenoic acid (DHA) and DHA-phosphatidylcholines (DHA-PCs) in dementia patients were reported previously. Recently, we have reported that supplementation of green nut oil (GNO) or DHA improves memory function and dist...

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Main Authors: Ariful Islam, Emiko Takeyama, Md. Al Mamun, Tomohito Sato, Makoto Horikawa, Yutaka Takahashi, Kenji Kikushima, Mitsutoshi Setou
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/10/4/153
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author Ariful Islam
Emiko Takeyama
Md. Al Mamun
Tomohito Sato
Makoto Horikawa
Yutaka Takahashi
Kenji Kikushima
Mitsutoshi Setou
author_facet Ariful Islam
Emiko Takeyama
Md. Al Mamun
Tomohito Sato
Makoto Horikawa
Yutaka Takahashi
Kenji Kikushima
Mitsutoshi Setou
author_sort Ariful Islam
collection DOAJ
description Dementia is a major public health concern nowadays. Reduced levels of brain docosahexaenoic acid (DHA) and DHA-phosphatidylcholines (DHA-PCs) in dementia patients were reported previously. Recently, we have reported that supplementation of green nut oil (GNO) or DHA improves memory function and distribution levels of brain DHA in senescence accelerated mice P8 (SAMP8). GNO is extracted from <i>Plukenetia volubilis</i> seeds, and SAMP8 is a well-known model mouse of dementia. In this current study, we examined the results of GNO or DHA supplementation in the distribution levels of brain DHA-PCs in same model mouse of dementia using desorption electrospray ionization (DESI) mass spectrometry imaging (MSI). We observed significantly decreased distribution of brain DHA-PCs, PC (16:0_22:6), and PC (18:0_22:6) in SAMP8 mice compared to wild type mice, and GNO or DHA treatment restored the decreased distribution levels of PC (16:0_22:6) and PC (18:0_22:6) in the brain of SAMP8 mice. These results indicate that GNO or DHA supplementation can ameliorate the decreased distribution of brain DHA-PCs in dementia, and could be potentially used for the prevention and treatment of dementia.
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spelling doaj.art-94c7a325c3f24c65a08fed60cdf5dfb42023-11-19T21:46:53ZengMDPI AGMetabolites2218-19892020-04-0110415310.3390/metabo10040153Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of DementiaAriful Islam0Emiko Takeyama1Md. Al Mamun2Tomohito Sato3Makoto Horikawa4Yutaka Takahashi5Kenji Kikushima6Mitsutoshi Setou7Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Food Science and Nutrition, Graduate School of Human Life Sciences, Showa Women’s University, Taishido, Setagaya-ku, Tokyo 154-8533, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, JapanDementia is a major public health concern nowadays. Reduced levels of brain docosahexaenoic acid (DHA) and DHA-phosphatidylcholines (DHA-PCs) in dementia patients were reported previously. Recently, we have reported that supplementation of green nut oil (GNO) or DHA improves memory function and distribution levels of brain DHA in senescence accelerated mice P8 (SAMP8). GNO is extracted from <i>Plukenetia volubilis</i> seeds, and SAMP8 is a well-known model mouse of dementia. In this current study, we examined the results of GNO or DHA supplementation in the distribution levels of brain DHA-PCs in same model mouse of dementia using desorption electrospray ionization (DESI) mass spectrometry imaging (MSI). We observed significantly decreased distribution of brain DHA-PCs, PC (16:0_22:6), and PC (18:0_22:6) in SAMP8 mice compared to wild type mice, and GNO or DHA treatment restored the decreased distribution levels of PC (16:0_22:6) and PC (18:0_22:6) in the brain of SAMP8 mice. These results indicate that GNO or DHA supplementation can ameliorate the decreased distribution of brain DHA-PCs in dementia, and could be potentially used for the prevention and treatment of dementia.https://www.mdpi.com/2218-1989/10/4/153dementiagreen nut oilDHASAMP8 miceDHA-PCsDESI-MSI
spellingShingle Ariful Islam
Emiko Takeyama
Md. Al Mamun
Tomohito Sato
Makoto Horikawa
Yutaka Takahashi
Kenji Kikushima
Mitsutoshi Setou
Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
Metabolites
dementia
green nut oil
DHA
SAMP8 mice
DHA-PCs
DESI-MSI
title Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
title_full Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
title_fullStr Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
title_full_unstemmed Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
title_short Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
title_sort green nut oil or dha supplementation restored decreased distribution levels of dha containing phosphatidylcholines in the brain of a mouse model of dementia
topic dementia
green nut oil
DHA
SAMP8 mice
DHA-PCs
DESI-MSI
url https://www.mdpi.com/2218-1989/10/4/153
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