Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms
For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only just...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/12/3240 |
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| author | Michael Zeinoun Javier Domingo-Diez Miguel Rodriguez-Garcia Oscar Garcia Miroslav Vasic Milagros Ramos José Javier Serrano Olmedo |
| author_facet | Michael Zeinoun Javier Domingo-Diez Miguel Rodriguez-Garcia Oscar Garcia Miroslav Vasic Milagros Ramos José Javier Serrano Olmedo |
| author_sort | Michael Zeinoun |
| collection | DOAJ |
| description | For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal is its availability and the facility to produce it. Following the development of a configurable alternating magnetic field generator, we aim to study the effect of various waveforms on the heat production effectiveness of magnetic nanoparticles, seeking to prove that signals with more significant slope values, such as the trapezoidal and almost-square signals, allow the nanoparticles to reach higher efficiency in heat generation. Furthermore, we seek to point out that the nanoparticle power dissipation is dependent on the waveform’s slope and not only the frequency, magnetic field intensity and the nanoparticle size. The experimental results showed a remarkably higher heat production performance of the nanoparticles when exposed to trapezoidal and almost-square signals than conventional sinusoidal signals. We conclude that the nanoparticles respond better to the trapezoidal and almost-square signals. On the other hand, the experimental results were used to calculate the normalized power dissipation value and prove its dependency on the slope. However, adjustments are necessary to the coil before proceeding with in vitro and in vivo studies to handle the magnetic fields required. |
| first_indexed | 2024-03-10T03:27:28Z |
| format | Article |
| id | doaj.art-94c84f34320346d6a71a148cf40e495c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:27:28Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-94c84f34320346d6a71a148cf40e495c2023-11-23T09:49:51ZengMDPI AGNanomaterials2079-49912021-11-011112324010.3390/nano11123240Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field WaveformsMichael Zeinoun0Javier Domingo-Diez1Miguel Rodriguez-Garcia2Oscar Garcia3Miroslav Vasic4Milagros Ramos5José Javier Serrano Olmedo6Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus Montegancedo, 28233 Madrid, SpainCenter for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus Montegancedo, 28233 Madrid, SpainCenter for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus Montegancedo, 28233 Madrid, SpainCentro de Electrónica Industrial, Universidad Politécnica de Madrid (UPM), 28006 Madrid, SpainCentro de Electrónica Industrial, Universidad Politécnica de Madrid (UPM), 28006 Madrid, SpainCenter for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus Montegancedo, 28233 Madrid, SpainCenter for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus Montegancedo, 28233 Madrid, SpainFor decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal is its availability and the facility to produce it. Following the development of a configurable alternating magnetic field generator, we aim to study the effect of various waveforms on the heat production effectiveness of magnetic nanoparticles, seeking to prove that signals with more significant slope values, such as the trapezoidal and almost-square signals, allow the nanoparticles to reach higher efficiency in heat generation. Furthermore, we seek to point out that the nanoparticle power dissipation is dependent on the waveform’s slope and not only the frequency, magnetic field intensity and the nanoparticle size. The experimental results showed a remarkably higher heat production performance of the nanoparticles when exposed to trapezoidal and almost-square signals than conventional sinusoidal signals. We conclude that the nanoparticles respond better to the trapezoidal and almost-square signals. On the other hand, the experimental results were used to calculate the normalized power dissipation value and prove its dependency on the slope. However, adjustments are necessary to the coil before proceeding with in vitro and in vivo studies to handle the magnetic fields required.https://www.mdpi.com/2079-4991/11/12/3240hyperthermiamagnetic nanoparticlessuperparamagneticiron oxidenanomedicinealternating magnetic field |
| spellingShingle | Michael Zeinoun Javier Domingo-Diez Miguel Rodriguez-Garcia Oscar Garcia Miroslav Vasic Milagros Ramos José Javier Serrano Olmedo Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms Nanomaterials hyperthermia magnetic nanoparticles superparamagnetic iron oxide nanomedicine alternating magnetic field |
| title | Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms |
| title_full | Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms |
| title_fullStr | Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms |
| title_full_unstemmed | Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms |
| title_short | Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms |
| title_sort | enhancing magnetic hyperthermia nanoparticle heating efficiency with non sinusoidal alternating magnetic field waveforms |
| topic | hyperthermia magnetic nanoparticles superparamagnetic iron oxide nanomedicine alternating magnetic field |
| url | https://www.mdpi.com/2079-4991/11/12/3240 |
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