The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

Hypoxia-inducible transcription factors (HIFs) drive angiogenesis and cancer cell growth, contributing to an aggressive tumor phenotype. HIF-α protein levels and activity are controlled at the post-translational level by HIF hydroxylases. Hydroxylated HIF-α is recognized by the von Hippel Lindau (VH...

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Bibliographic Details
Main Authors: Christina Wohlrab, Margreet C. M. Vissers, Elisabeth Phillips, Helen Morrin, Bridget A. Robinson, Gabi U. Dachs
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Oncology
Subjects:
clear cell renal cell carcinoma
papillary renal cell carcinoma
HIF-1
HIF-2
vitamin C
VHL
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00574/full

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