Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial
Abstract In this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark RO...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12894-023-01385-5 |
| _version_ | 1797349661589110784 |
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| author | Haidar Hadri bin Abd Wahab Michael O’Callaghan |
| author_facet | Haidar Hadri bin Abd Wahab Michael O’Callaghan |
| author_sort | Haidar Hadri bin Abd Wahab |
| collection | DOAJ |
| description | Abstract In this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomised trial allocated females 1:1 to receive Sacral Neuromodulation (SNM) or OnabotulinumtoxinA(BTX) 200 units (U). The primary outcome was change in mean daily urinary urgency incontinence episodes (UUIE) over 24 months. The study did not demonstrate a difference between treatments (-3.88 vs. -3.50 episodes per day), however women treated with BTX were more satisfied; but reported higher rates of UTI. The two treatments provide comparable third-line treatment options for patients with refractory urgency urinary incontinence. |
| first_indexed | 2024-03-08T12:33:32Z |
| format | Article |
| id | doaj.art-94c94321d38844549f5b7ae007e69189 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-08T12:33:32Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-94c94321d38844549f5b7ae007e691892024-01-21T12:36:54ZengBMCBMC Urology1471-24902024-01-012411310.1186/s12894-023-01385-5Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized TrialHaidar Hadri bin Abd Wahab0Michael O’Callaghan1Urology Unit, Flinders Medical CentreUrology Unit, Flinders Medical CentreAbstract In this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomised trial allocated females 1:1 to receive Sacral Neuromodulation (SNM) or OnabotulinumtoxinA(BTX) 200 units (U). The primary outcome was change in mean daily urinary urgency incontinence episodes (UUIE) over 24 months. The study did not demonstrate a difference between treatments (-3.88 vs. -3.50 episodes per day), however women treated with BTX were more satisfied; but reported higher rates of UTI. The two treatments provide comparable third-line treatment options for patients with refractory urgency urinary incontinence.https://doi.org/10.1186/s12894-023-01385-5Urinary incontinenceRandomized controlled trialSacral NeuromodulationOnabotulinumtoxinA |
| spellingShingle | Haidar Hadri bin Abd Wahab Michael O’Callaghan Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial BMC Urology Urinary incontinence Randomized controlled trial Sacral Neuromodulation OnabotulinumtoxinA |
| title | Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial |
| title_full | Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial |
| title_fullStr | Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial |
| title_full_unstemmed | Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial |
| title_short | Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial |
| title_sort | seminal papers in urology two year outcomes of sacral neuromodulation versus onabotulinumtoxina for refractory urgency urinary incontinence a randomized trial |
| topic | Urinary incontinence Randomized controlled trial Sacral Neuromodulation OnabotulinumtoxinA |
| url | https://doi.org/10.1186/s12894-023-01385-5 |
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