Targeting tumor-associated macrophages for cancer treatment

Targeting tumor-associated macrophages for cancer treatment

Abstract Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like phenotype in advanced cancer, which plays a crucial role in tumor growth, invasion and migration, angiogenesis and immunos...

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Bibliographic Details
Main Authors: Mengjun Li, Linye He, Jing Zhu, Peng Zhang, Shufang Liang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Cell & Bioscience
Subjects:
Tumor-associated macrophages
Tumor microenvironment
TAM-targeting therapy
Anticancer therapies
Immunotherapy
Online Access:https://doi.org/10.1186/s13578-022-00823-5

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