Oropharyngeal Candidosis in HIV-Infected Patients—An Update
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated. OPC usually presents months or years before other severe opportu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00980/full |
| _version_ | 1818466086350225408 |
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| author | Shankargouda Patil Barnali Majumdar Sachin C. Sarode Gargi S. Sarode Kamran H. Awan |
| author_facet | Shankargouda Patil Barnali Majumdar Sachin C. Sarode Gargi S. Sarode Kamran H. Awan |
| author_sort | Shankargouda Patil |
| collection | DOAJ |
| description | Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated. OPC usually presents months or years before other severe opportunistic infections and may indicate the presence or progression of HIV disease. The concept of OPC as a biofilm infection has changed our understanding of its pathobiology. Various anti-fungal agents (both topical and systemic) are available to treat OPC. However, anti-fungal resistance as a result of the long-term use of anti-fungal agents and recurrent oropharyngeal infection in AIDS patients require alternative anti-fungal therapies. In addition, both identifying the causative Candida species and conducting anti-fungal vulnerability testing can improve a clinician's ability to prescribe effective anti-fungal agents. The present review focuses on the current findings and therapeutic challenges for HIV-infected patients with OPC. |
| first_indexed | 2024-04-13T20:53:47Z |
| format | Article |
| id | doaj.art-94cb4adc6adb4119b47afdb0eb2389e5 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T20:53:47Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-94cb4adc6adb4119b47afdb0eb2389e52022-12-22T02:30:24ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-05-01910.3389/fmicb.2018.00980356560Oropharyngeal Candidosis in HIV-Infected Patients—An UpdateShankargouda Patil0Barnali Majumdar1Sachin C. Sarode2Gargi S. Sarode3Kamran H. Awan4Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jizan, Saudi ArabiaDepartment of Oral Pathology and Microbiology, Bhojia Dental College & Hospital, Baddi, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, IndiaCollege of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT, United StatesOropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated. OPC usually presents months or years before other severe opportunistic infections and may indicate the presence or progression of HIV disease. The concept of OPC as a biofilm infection has changed our understanding of its pathobiology. Various anti-fungal agents (both topical and systemic) are available to treat OPC. However, anti-fungal resistance as a result of the long-term use of anti-fungal agents and recurrent oropharyngeal infection in AIDS patients require alternative anti-fungal therapies. In addition, both identifying the causative Candida species and conducting anti-fungal vulnerability testing can improve a clinician's ability to prescribe effective anti-fungal agents. The present review focuses on the current findings and therapeutic challenges for HIV-infected patients with OPC.http://journal.frontiersin.org/article/10.3389/fmicb.2018.00980/fullAIDSantifungalsCandidaHIVopportunistic infectionsOropharyngeal candidosis |
| spellingShingle | Shankargouda Patil Barnali Majumdar Sachin C. Sarode Gargi S. Sarode Kamran H. Awan Oropharyngeal Candidosis in HIV-Infected Patients—An Update Frontiers in Microbiology AIDS antifungals Candida HIV opportunistic infections Oropharyngeal candidosis |
| title | Oropharyngeal Candidosis in HIV-Infected Patients—An Update |
| title_full | Oropharyngeal Candidosis in HIV-Infected Patients—An Update |
| title_fullStr | Oropharyngeal Candidosis in HIV-Infected Patients—An Update |
| title_full_unstemmed | Oropharyngeal Candidosis in HIV-Infected Patients—An Update |
| title_short | Oropharyngeal Candidosis in HIV-Infected Patients—An Update |
| title_sort | oropharyngeal candidosis in hiv infected patients an update |
| topic | AIDS antifungals Candida HIV opportunistic infections Oropharyngeal candidosis |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00980/full |
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