Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion
Objective: improving the algorithm for the management of patients with viral hepatitis using contrast-free arterial spin labelling (ASL) magnetic resonance (MR) perfusion.Material and methods. A total of 116 patients with viral hepatitis (VH) B, C and B + C were examined on the basis of Clinical hos...
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2021-11-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/667 |
| _version_ | 1797341631426330624 |
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| author | E. N. Simakina T. G. Morozova |
| author_facet | E. N. Simakina T. G. Morozova |
| author_sort | E. N. Simakina |
| collection | DOAJ |
| description | Objective: improving the algorithm for the management of patients with viral hepatitis using contrast-free arterial spin labelling (ASL) magnetic resonance (MR) perfusion.Material and methods. A total of 116 patients with viral hepatitis (VH) B, C and B + C were examined on the basis of Clinical hospital No. 1 (Smolensk): 75 (64.7%) men and 41 (35.3%) women, mean age 49.7 ± 2.3 years. The patients underwent instrumental diagnostic methods: ultrasound, clinical elastography, contrast-free hepatic ASL MR perfusion. Liver biopsy (n = 57) was used as the reference method.Results. The results of ASL MR perfusion had a high correlation with the data of clinical elastography in the diagnosis of fibrotic process; the diagnostic and prognostic significance of ASL liver perfusion in the diagnosis of fibrotic process was: AUROC 0.943 (95% CI, 0.884–0.953). There was a high correlation between ASL MR perfusion with Doppler ultrasound of hepatic blood vessels in the diagnosis of arterial blood flow disorders, but in VH В + C and cirrhosis – diagnostic and prognostic significance of the method: AUROC 0.951 (95% CI 0.932–0.972).Conclusion. ASL MR perfusion in VH patients allows to predict fibrotic changes in the hepatic parenchyma (AUROC 0.934 (95% CI 0.845–0.957)), provides information about changes in blood flow in the parenchymal structure (p < 0.005). The algorithm for the examination of VH patients should include contrast-free ASL MR perfusion at admission (AUROC 0.865 (95% CI 0.843–0.928)) and in dynamic follow-up (AUROC 0.915 (95% CI 0.881–0.946)). |
| first_indexed | 2024-03-08T10:21:48Z |
| format | Article |
| id | doaj.art-94cb7ae18bd04adcbf9757c5e4cb01c2 |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:21:48Z |
| publishDate | 2021-11-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-94cb7ae18bd04adcbf9757c5e4cb01c22024-01-27T18:38:37ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782021-11-01102527628310.20862/0042-4676-2021-102-5-276-283390Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance PerfusionE. N. Simakina0T. G. Morozova1Smolensk State Medical University, Ministry of HealthSmolensk State Medical University, Ministry of HealthObjective: improving the algorithm for the management of patients with viral hepatitis using contrast-free arterial spin labelling (ASL) magnetic resonance (MR) perfusion.Material and methods. A total of 116 patients with viral hepatitis (VH) B, C and B + C were examined on the basis of Clinical hospital No. 1 (Smolensk): 75 (64.7%) men and 41 (35.3%) women, mean age 49.7 ± 2.3 years. The patients underwent instrumental diagnostic methods: ultrasound, clinical elastography, contrast-free hepatic ASL MR perfusion. Liver biopsy (n = 57) was used as the reference method.Results. The results of ASL MR perfusion had a high correlation with the data of clinical elastography in the diagnosis of fibrotic process; the diagnostic and prognostic significance of ASL liver perfusion in the diagnosis of fibrotic process was: AUROC 0.943 (95% CI, 0.884–0.953). There was a high correlation between ASL MR perfusion with Doppler ultrasound of hepatic blood vessels in the diagnosis of arterial blood flow disorders, but in VH В + C and cirrhosis – diagnostic and prognostic significance of the method: AUROC 0.951 (95% CI 0.932–0.972).Conclusion. ASL MR perfusion in VH patients allows to predict fibrotic changes in the hepatic parenchyma (AUROC 0.934 (95% CI 0.845–0.957)), provides information about changes in blood flow in the parenchymal structure (p < 0.005). The algorithm for the examination of VH patients should include contrast-free ASL MR perfusion at admission (AUROC 0.865 (95% CI 0.843–0.928)) and in dynamic follow-up (AUROC 0.915 (95% CI 0.881–0.946)).https://www.russianradiology.ru/jour/article/view/667arterial spin labelling magnetic resonance perfusionmagnetic resonance imagingviral hepatitis |
| spellingShingle | E. N. Simakina T. G. Morozova Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion Вестник рентгенологии и радиологии arterial spin labelling magnetic resonance perfusion magnetic resonance imaging viral hepatitis |
| title | Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion |
| title_full | Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion |
| title_fullStr | Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion |
| title_full_unstemmed | Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion |
| title_short | Improving the Algorithm for the Management of Patients with Viral Hepatitis Using Contrast-Free Hepatic Arterial Spin Labelling Magnetic Resonance Perfusion |
| title_sort | improving the algorithm for the management of patients with viral hepatitis using contrast free hepatic arterial spin labelling magnetic resonance perfusion |
| topic | arterial spin labelling magnetic resonance perfusion magnetic resonance imaging viral hepatitis |
| url | https://www.russianradiology.ru/jour/article/view/667 |
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