Association of hemoglobin A1c with the incidence of hypertension: A large prospective study
BackgroundAlthough hemoglobin A1c (HbA1c) is closely related to diabetes, its relationship with the incidence of hypertension is still unknown, so we aimed to evaluate the relationship between HbA1c and the incidence of hypertension in the general population.MethodIn this large prospective cohort st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1098012/full |
| _version_ | 1797952082916933632 |
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| author | Xu Huang Cheng Qin Xiaoxu Guo Feng Cao Chengchun Tang |
| author_facet | Xu Huang Cheng Qin Xiaoxu Guo Feng Cao Chengchun Tang |
| author_sort | Xu Huang |
| collection | DOAJ |
| description | BackgroundAlthough hemoglobin A1c (HbA1c) is closely related to diabetes, its relationship with the incidence of hypertension is still unknown, so we aimed to evaluate the relationship between HbA1c and the incidence of hypertension in the general population.MethodIn this large prospective cohort study with a median follow-up of 2 years, we included 4,074 participants from the China Health and Nutrition Survey (CHNS). Multivariate COX regression, subgroup analysis, receiver operator characteristic (ROC) curve and restricted cubic spline (RCS) were used to evaluate the relationship between HbA1c and incidental hypertension.ResultsCompared with participants without incident hypertension, participants with incident hypertension had higher levels of HbA1c (P < 0.05). In univariate COX regression analysis, HbA1c was associated with the risk of hypertension (HR: 1.161, 95% CI: 1.105-1.221, P < 0.001). In multivariate COX regression analysis adjusted for confounding variables, HbA1c was still closely related to the risk of hypertension (HR: 1.102, 95% CI: 1.006-1.206, P = 0.037). And subgroup analysis showed that the relationship between HbA1c and hypertension remained significant in female, lower than high school and non-obese subgroups (P < 0.05). ROC curve also showed that HbA1c could predict the risk of hypertension (AUC = 0.583, 95% CI: 0.568-0.598, P < 0.001). Further RCS analysis showed that HbA1c was positively correlated with the risk of hypertension (P for nonlinearity = 0.642).ConclusionHbA1c was linearly and positively associated with the incidence of hypertension. |
| first_indexed | 2024-04-10T22:41:55Z |
| format | Article |
| id | doaj.art-94cc41f57c2b4657a6d21fc6c85c2d80 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T22:41:55Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-94cc41f57c2b4657a6d21fc6c85c2d802023-01-16T04:53:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10980121098012Association of hemoglobin A1c with the incidence of hypertension: A large prospective studyXu Huang0Cheng Qin1Xiaoxu Guo2Feng Cao3Chengchun Tang4Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Digestive Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, ChinaDepartment of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaBackgroundAlthough hemoglobin A1c (HbA1c) is closely related to diabetes, its relationship with the incidence of hypertension is still unknown, so we aimed to evaluate the relationship between HbA1c and the incidence of hypertension in the general population.MethodIn this large prospective cohort study with a median follow-up of 2 years, we included 4,074 participants from the China Health and Nutrition Survey (CHNS). Multivariate COX regression, subgroup analysis, receiver operator characteristic (ROC) curve and restricted cubic spline (RCS) were used to evaluate the relationship between HbA1c and incidental hypertension.ResultsCompared with participants without incident hypertension, participants with incident hypertension had higher levels of HbA1c (P < 0.05). In univariate COX regression analysis, HbA1c was associated with the risk of hypertension (HR: 1.161, 95% CI: 1.105-1.221, P < 0.001). In multivariate COX regression analysis adjusted for confounding variables, HbA1c was still closely related to the risk of hypertension (HR: 1.102, 95% CI: 1.006-1.206, P = 0.037). And subgroup analysis showed that the relationship between HbA1c and hypertension remained significant in female, lower than high school and non-obese subgroups (P < 0.05). ROC curve also showed that HbA1c could predict the risk of hypertension (AUC = 0.583, 95% CI: 0.568-0.598, P < 0.001). Further RCS analysis showed that HbA1c was positively correlated with the risk of hypertension (P for nonlinearity = 0.642).ConclusionHbA1c was linearly and positively associated with the incidence of hypertension.https://www.frontiersin.org/articles/10.3389/fendo.2022.1098012/fullglycated hemoglobinhemoglobin A1chypertensionprevalenceincidence |
| spellingShingle | Xu Huang Cheng Qin Xiaoxu Guo Feng Cao Chengchun Tang Association of hemoglobin A1c with the incidence of hypertension: A large prospective study Frontiers in Endocrinology glycated hemoglobin hemoglobin A1c hypertension prevalence incidence |
| title | Association of hemoglobin A1c with the incidence of hypertension: A large prospective study |
| title_full | Association of hemoglobin A1c with the incidence of hypertension: A large prospective study |
| title_fullStr | Association of hemoglobin A1c with the incidence of hypertension: A large prospective study |
| title_full_unstemmed | Association of hemoglobin A1c with the incidence of hypertension: A large prospective study |
| title_short | Association of hemoglobin A1c with the incidence of hypertension: A large prospective study |
| title_sort | association of hemoglobin a1c with the incidence of hypertension a large prospective study |
| topic | glycated hemoglobin hemoglobin A1c hypertension prevalence incidence |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1098012/full |
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