Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery
Study objective: Data is scarce regarding which dialysis modality portends more severe cardiac valvular calcification (CVC). Our aim was to compare the degree of CVC in hemodialysis (HD) and peritoneal dialysis (PD) patient cohorts prior to open heart surgery (OHS) using a CT calcium score. Design,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222001513 |
| _version_ | 1797961219558080512 |
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| author | Christopher N. Kanaan Habib Layoun Nicholas P. Kondoleon Remy Fadel Saeid Mirzai Jesse Schold Susana Arrigain Remy Daou Ali Mehdi Jonathan J. Taliercio Shinya Unai Samir Kapadia Serge Harb Georges N. Nakhoul |
| author_facet | Christopher N. Kanaan Habib Layoun Nicholas P. Kondoleon Remy Fadel Saeid Mirzai Jesse Schold Susana Arrigain Remy Daou Ali Mehdi Jonathan J. Taliercio Shinya Unai Samir Kapadia Serge Harb Georges N. Nakhoul |
| author_sort | Christopher N. Kanaan |
| collection | DOAJ |
| description | Study objective: Data is scarce regarding which dialysis modality portends more severe cardiac valvular calcification (CVC). Our aim was to compare the degree of CVC in hemodialysis (HD) and peritoneal dialysis (PD) patient cohorts prior to open heart surgery (OHS) using a CT calcium score. Design, setting, and participants: Dialysis patients who underwent OHS at our institution from 2009 to 2019 and who had pre-surgical cardiac CT were included in our study. We obtained duration of dialysis modality prior to their surgical date. There were two study cohorts to evaluate outcomes of interest: mitral and aortic calcification. CVC was assessed using the Agatston score. Logistic regression was performed to test for the association of PD and HD cumulative dialysis duration with presence of CVC. Results: A total of 214 and 166 patients met inclusion for the mitral and aortic strata, respectively. Age, female sex, and BMI were associated with higher odds of presence of mitral calcification. Age and BMI were associated with higher odds of presence of aortic calcification, while female sex was associated with lower odds in the aortic strata. Cumulative years on PD and cumulative years on HD were not significantly associated with presence of CVC in either cohort. Conclusion: Presence of mitral and aortic calcification for patients undergoing OHS was not significantly associated with cumulative length of PD or HD after adjusting for age, gender, and BMI suggesting that there may be more factors at play in the progression of CVC in end stage renal disease patients than what was previously established. |
| first_indexed | 2024-04-11T00:55:38Z |
| format | Article |
| id | doaj.art-94ccb41a5d694b59b3c4357b073b1f1e |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-11T00:55:38Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-94ccb41a5d694b59b3c4357b073b1f1e2023-01-05T04:32:49ZengElsevierAmerican Heart Journal Plus2666-60222023-01-0125100234Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgeryChristopher N. Kanaan0Habib Layoun1Nicholas P. Kondoleon2Remy Fadel3Saeid Mirzai4Jesse Schold5Susana Arrigain6Remy Daou7Ali Mehdi8Jonathan J. Taliercio9Shinya Unai10Samir Kapadia11Serge Harb12Georges N. Nakhoul13Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USARobert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, USASaint Joseph University, Department of Family Medicine, Beirut, LebanonDepartment of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USARobert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USARobert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Corresponding author at: Department of Nephrology and Hypertension, Cleveland Clinic, Q7, 9500 Euclid Avenue, Cleveland, OH 44195, USA.Study objective: Data is scarce regarding which dialysis modality portends more severe cardiac valvular calcification (CVC). Our aim was to compare the degree of CVC in hemodialysis (HD) and peritoneal dialysis (PD) patient cohorts prior to open heart surgery (OHS) using a CT calcium score. Design, setting, and participants: Dialysis patients who underwent OHS at our institution from 2009 to 2019 and who had pre-surgical cardiac CT were included in our study. We obtained duration of dialysis modality prior to their surgical date. There were two study cohorts to evaluate outcomes of interest: mitral and aortic calcification. CVC was assessed using the Agatston score. Logistic regression was performed to test for the association of PD and HD cumulative dialysis duration with presence of CVC. Results: A total of 214 and 166 patients met inclusion for the mitral and aortic strata, respectively. Age, female sex, and BMI were associated with higher odds of presence of mitral calcification. Age and BMI were associated with higher odds of presence of aortic calcification, while female sex was associated with lower odds in the aortic strata. Cumulative years on PD and cumulative years on HD were not significantly associated with presence of CVC in either cohort. Conclusion: Presence of mitral and aortic calcification for patients undergoing OHS was not significantly associated with cumulative length of PD or HD after adjusting for age, gender, and BMI suggesting that there may be more factors at play in the progression of CVC in end stage renal disease patients than what was previously established.http://www.sciencedirect.com/science/article/pii/S2666602222001513Cardiac valvular calcificationHemodialysisPeritoneal dialysisCTCardiac surgery |
| spellingShingle | Christopher N. Kanaan Habib Layoun Nicholas P. Kondoleon Remy Fadel Saeid Mirzai Jesse Schold Susana Arrigain Remy Daou Ali Mehdi Jonathan J. Taliercio Shinya Unai Samir Kapadia Serge Harb Georges N. Nakhoul Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery American Heart Journal Plus Cardiac valvular calcification Hemodialysis Peritoneal dialysis CT Cardiac surgery |
| title | Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| title_full | Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| title_fullStr | Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| title_full_unstemmed | Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| title_short | Comparison of CT acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| title_sort | comparison of ct acquired cardiac valvular calcification scores in hemodialysis and peritoneal dialysis patients undergoing open heart surgery |
| topic | Cardiac valvular calcification Hemodialysis Peritoneal dialysis CT Cardiac surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222001513 |
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